The Effect of Cortisol Administration on Neural Correlates of Emotion in Depression
Completed · Early Phase 1 · Has a placebo group
Conditions studied: Depression
In brief
There is good evidence to suggest that the pathological version of sadness that people with Major Depression experience could be caused by the failure of the hormone cortisol to properly inhibit sadness-related brain activity in the subgenual cingulate cortex. This project investigates if the subgenual cingulate cortex has become insensitive to cortisol in patients with depression and tests for variants of the cortisol receptor genes that could predispose individuals to develop cortisol insensitivity.
Key facts
- Study ID
- NCT02837432
- Run by
- Stanford University
- People needed
- 192
- Starts
- 2016-07-01
- Expected to finish
- 2020-11-15
- Last updated by the study team
- 2021-10-22
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy Participants must have no Axis 1 mental disorder
- Participants with depression must meet minimum severity levels (Hamilton >7)
- All participants must weight less than 280 pounds for the purposes of MRI scanning
You may not qualify if…
- In order to protect against risk associated with taking Hydrocortisone, all participants must not have any of the following:
- Psychotropic medications
- Recent surgery
- Endocrine disorders
- Liver disease
- Kidney disease
- Thyroid disorder
- History of malaria
- Tuberculosis
- Osteoporosis
- Glaucoma/cataracts
- Chronic expressed infections (herpes --including ocular herpes, HIV, etc.)
- History of congestive heart failure
- History of recurring seizures
- Stomach Ulcers
- Comorbid psychosis
- Current use of illicit drugs
- High Blood pressure
- In order to protect against risks associated with MRI scanning participants must not be/have any of the following:
- >280 lbs
- In-dwelling ferrous metals
- Left Handed
- Abnormal Hearing
- Claustrophobic
- Head injury with loss of consciousness
Where it is running
- Department of Psychiatry and Behavioral Sciences, 401 Quarry Road — Stanford, California, United States
Full record on ClinicalTrials.gov
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