Intestinal Sweet Taste Receptor Function and Adaptation to Dietary Sugars and Sweeteners

Completed · Not applicable

Conditions studied: Diabetes

In brief

The purpose of this study is to collect data that will help researchers better understand the various causes of obesity and diabetes; particularly to understand how consumption of NCASs affects the way the body uses nutrients.

Key facts

Study ID

NCT02835859

Run by

AdventHealth Translational Research Institute

People needed

10

Starts

2014-08-01

Expected to finish

2017-09-01

Last updated by the study team

2020-08-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-65 years inclusive;
• Men and women;
• Able to provide written, informed consent;
• Weight stable (± 3 kg) during the 3 months prior to enrollment;
• BMI ≤ 25 kg/m2

You may not qualify if…

• Diagnosed with any of the following co-morbidities: a) coronary artery disease, angina or heart failure, b) diabetes, c) bleeding disorders, d) infections, e) hepatitis and/or cirrhosis, f) severe asthma or chronic obstructive pulmonary disorder, g) renal insufficiency, h) bariatric surgery, i) inflammatory bowel disease or malabsorption, j) cancer within the last 3 years (except non-melanoma skin cancer or treated cervical carcinoma in situ), k) psychiatric or eating disorders, l) untreated or inadequately controlled thyroid or other endocrine disorders, m) active rheumatoid arthritis or other inflammatory rheumatic disorder;
• Consumption of more than a can of diet beverage or a spoonful of non-caloric artificial sweeteners weekly (or each equivalent from foods) during the past month.
• Pregnant or nursing women;
• Current smokers (smoking within the past 3 months);
• Known hypersensitivity to saccharin, lactisole, and acetaminophen or any of its exipients;
• History of difficult blood sample collections or unfavorable anatomy of venous access;
• Use of medications: a) nitrates, b) beta-blockers, c) digoxin, d) anti-diabetic agents, e) oral, injected or chronic topical steroids (inhaled steroids for mild asthma are acceptable), f) chronic use of aspirin or other non-steroidal anti-inflammatory drugs, g) other drugs known to affect immune or metabolic function and h) orlistat, phentermine or other weight loss or anorectic agents.
• Blood pressure greater than or equal to 160/100 or less than or equal to 100/50 at screening.

Where it is running

• Translational Research Institute for Metabolism and Diabetes — Orlando, Florida, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.