Use of an Experimental Drug, CC-115, With Enzalutamide in Men With Castration-Resistant Prostate Cancer

Completed · Phase 1

Conditions studied: Prostate Cancer, Castration Resistant Prostate Cancer

In brief

The main purpose of this study to define the good and/or bad effects of the combination of enzalutamide and CC-115 in patients with castration-resistant prostate cancer.

Key facts

Study ID

NCT02833883

Run by

Memorial Sloan Kettering Cancer Center

People needed

40

Starts

2016-07-01

Expected to finish

2023-01-13

Last updated by the study team

2023-01-19

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Willing and able to provide written informed consent and HIPAA authorization for the release of personal health information.
• NOTE: HIPAA authorization may be either included in the informed consent or obtained separately.
• Males 18 years of age and above with a life expectancy of at least 6 months.
• Histological or cytological proof of prostate cancer
• Willing to provide a tumor sample via biopsy from a metastatic site of disease to be collected at screening if safe and feasible per treating investigator discretion. Adequate archival tissue can be used if available in lieu of baseline biopsy.
• Documented progressive metastatic CRPC based on at least one of the following criteria:
• Rise in PSA: a minimum of 3 rising levels, with an interval of at least 1 week between each determination. The last determination must have a value ≥1 ng/mL, obtained within 4 weeks of starting study drug
• Measurable disease: new or progressive soft tissue disease on computerized tomography (CT) or magnetic resonance imaging
• Radionuclide bone scan: at least 2 new bone lesions, as defined by the Prostate Cancer Clinical Trials Working Group 2 (PCWG2) criteria33
• Serum testosterone < 50 ng/dL. Patients must continue primary androgen deprivation with an LHRH analogue (agonist or antagonist) if they have not undergone orchiectomy
• ECOG performance status of 0-1
• Finasteride, bicalutamide and nilutamide discontinued at least 4 weeks prior to registration.
• Physiologic doses of corticosteroids are permitted (i.e., no more than 10mg of prednisone daily).
• At least 4 weeks must have elapsed from the use of palliative radiation, Strontium-89, Radium-223, or approved immunotherapy prior to registration.
• Less than or equal to 5 half lives or 4 weeks, whichever is shorter, from the use of any investigational therapy prior to registration.
• Normal organ function with acceptable initial laboratory values within 14 days of registration.
• ANC ≥ 1,500/μl
• Hemoglobin ≥ 9g/dL
• Platelet count ≥ 100,000/μl
• Creatinine ≤ 1.5 x the institutional upper limit of normal (ULN), or 24-hr clearance ≥50 mL/min
• Potassium ≥ 3.5 mmol/L (within institutional normal range, or correctable with supplements)
• Bilirubin ≤ 1.5 x ULN (unless documented Gilbert's disease)
• SGOT (AST) ≤ 2.5 x ULN
• SGPT (ALT) ≤ 2.5 x ULN
• Glycated hemoglobin (HbA1c < 6.4%

You may not qualify if…

• Prior exposure to enzalutamide, ARN-509, or other investigational AR-directed therapy
• Prior exposure to abiraterone acetate, ketoconazole or other specific CYP-17 inhibitors
• Prior exposure to agents specifically targeting both mTOR complexes (dual TORC1+TORC2 inhibitors) and/or PI3K/AKT pathways
• Prior chemotherapy for castration resistant disease. Chemotherapy given in the castration-sensitive setting is permissible. At least 6 months from registration must have elapsed since chemotherapy was last received.
• Symptomatic central nervous system metastases
• Known history of acute or chronic pancreatitis
• Persistent diarrhea or malabsorption ≥ NCI CTCAE Grade 2, despite medical management
• Clinically significant cardiac diseases, including any of the following:
• Unstable angina pectoris
• Myocardial infarction ≤ 3 months prior to registration
• Other clinically significant heart disease such as congestive heart failure requiring treatment or uncontrolled hypertension
• Uncontrolled diabetes mellitus
• Other concurrent severe and/or uncontrolled concomitant medical conditions (e.g., active or uncontrolled infection) that could cause unacceptable safety risks or compromise compliance with the protocol
• Major surgery ≤ 2 weeks prior to registration or who have not recovered from side effects of such therapy. Subjects must have recovered from any effects of recent radiotherapy that might confound the safety evaluation of study drug.
• Hematopoietic stem cell transplant ≤ 3 months prior to registration.
• Adults of reproductive potential not employing two forms of birth control:
• Males having partners who are female with child-bearing potential must agree that they and/or their partners will use at least two effective contraceptive methods (including one barrier method) when engaging in reproductive sexual activity throughout the study from the time of informed consent, and will avoid conceiving for 28 days after the last dose of CC-115.
• Known human immunodeficiency virus (HIV) infection
• Known chronic hepatitis B or C virus (HBV/HCV) infection
• Concurrent active second malignancy for which the subject is receiving therapy, other than non-melanomatous skin cancer or superficial transitional cell carcinoma.
• History of seizure or any condition that may predispose to seizure including, but not limited to, underlying brain injury, stroke in the past 6 months, primary brain tumors, brain metastases
• Active treatment with medications that lower the seizure threshold which cannot be held:
• Aminophylline/theophylline;
• Atypical antipsychotics (e.g., clozapine, olanzapine, risperidone, ziprasidone);
• Bupropion;

Where it is running

• University of California San Francisco — San Francisco, California, United States
• John Hopkins Medical Center — Baltimore, Maryland, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• University of Washington School of Medicine — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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