Evaluating the Effects of Acupuncture in the Treatment of Taxane Induces Peripheral Neuropathy

Completed · Not applicable

Conditions studied: Peripheral Neuropathy

In brief

Taxane Induced Peripheral Neuropathy (TIPN) is a major dose limiting side effect of taxane chemotherapies and it often reduces the success of the patient treatment. Treating TIPN is difficult and at this time conventional treatment is primarily limited to the global use of antidepressants and anticonvulsants. Acupuncture treatment has been used for symptom improvement in patients with peripheral neuropathy caused by HIV and diabetes mellitus; however, few studies have evaluated acupuncture as a viable treatment for taxane induced peripheral neuropathy. This study will enroll female breast cancer survivors at the Greenville Health System Cancer Institute Center for Integrative Oncology and Survivorship to assess whether acupuncture holds any therapeutic benefit for TIPN and how it influences the mechanisms underlying resolution of TIPN. This would provide critical validation of acupuncture and increase potential for other forms of chemotherapy induced peripheral neuropathy.

Key facts

Study ID

NCT02831114

Run by

Prisma Health-Upstate

People needed

18

Starts

2016-05-01

Expected to finish

2018-01-01

Last updated by the study team

2018-01-04

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed primary invasive carcinoma of the breast (stage I, II, or III)
• Completed active chemotherapeutic with taxane therapy (taxotere, Taxol, Abraxane) within the last 24 months
• Established diagnosis of motor and sensory neuropathy greater or equal to 2 according to the CTCAE v 4.03 scale in spite of previous treatment with Neurontin, Cymbalta and/or Lyrica
• Read, understand, and speak English

You may not qualify if…

• Currently undergoing active treatment with chemotherapy (not including TKI's or other targeted therapy)
• Any acupuncture treatment for any indication within the 30 days of enrollment
• Cardiac Pacemaker
• Deformities that interfere with accurate acupuncture point locations
• Local infection at or near the acupuncture site
• Pregnant or currently lactating
• Medical History of chronic alcohol use
• Mental incapacitation or significant emotional or psychological disorder

Where it is running

• Greenville Health System Cancer Institute Center for Integrative Oncology and Survivorship — Greenville, South Carolina, United States

Full record on ClinicalTrials.gov

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