Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair

Stopped early · Phase 2

Conditions studied: Infertility, Asherman's Syndrome

In brief

Patients with intrauterine adhesions (Asherman's Syndrome) and persistent thin endometrial lining in in vitro fertilization (IVF) treatment programs, particularly those resistant to standard therapies, present a significant clinical challenge. The aim of this trial is to assess if intrauterine administration of platelet rich plasma (PRP) improves endometrial lining thickness in patients with thin lining or Asherman's Syndrome.

Key facts

Study ID

NCT02825849

Run by

University of California, San Francisco

People needed

27

Starts

2016-11-01

Expected to finish

2019-08-01

Last updated by the study team

2021-02-09

Who can join

Age: 18 and older, up to 43. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Persistent thin lining < 6mm on >1 cycle in previous IVF or FET cycle OR moderate-to-severe Asherman's syndrome

You may not qualify if…

• Age <18 years old or >43 years old,
• Pregnancy,
• Diagnosis of cancer,
• Hb <11 g/dL, platelets <150,000/mm3,
• Anticoagulation,
• NSAIDs in the 10 days before procedure
• Any significant comorbidity or psychiatric disorder that would compromise patient safety or compliance, interfere with consent, study participation, follow up, or interpretation of study results.
• Incision in the uterus: myomectomy; cesarean section

Where it is running

• University of California San Francisco - Center for Reproductive Health — San Francisco, California, United States

Full record on ClinicalTrials.gov

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