Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?

Completed · Not applicable

Conditions studied: Substance Withdrawal Syndrome

In brief

The purpose of this study is to see whether adults who use e-cigarettes every day experience symptoms of nicotine withdrawal when they stop using e-cigarettes for 6 days.

Key facts

Study ID

NCT02825459

Run by

University of Vermont

People needed

147

Starts

2016-07-01

Expected to finish

2018-10-31

Last updated by the study team

2018-11-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 years or older
• Able to read and understand verbal English fluently
• US citizen or resident alien
• Primarily uses e-cigarette product types of refillable tanks or modified devices
• Uses nicotine-containing e-liquid
• Has baseline urinary cotinine concentration of > 100 ng/ml
• Has used e-cigarettes daily for the last 2 months
• Has a home or cell phone
• Agrees to abstain from tobacco, marijuana and other illegal drugs during study

You may not qualify if…

• Smoked > 5 tobacco cigarettes in the last month
• Used non-cigarette nicotine, tobacco or quit smoking products on >5 days in the past month
• Use of cannabis (either marijuana or synthetic cannabis) > 5 times in the past month or positive test for cannabis use at screening
• Current (last 6 months) Generalized Anxiety Disorder, Major Depressive Disorder, Attention Deficit Hyperactivity Disorder or moderate/severe Substance Abuse Disorder
• Multiple legal, social health, work or school problems in the past month due to alcohol or drug use
• Pregnant or breastfeeding
• Previously a participant in the current study
• Use of prescribed or non-prescribed psychoactive medication > 5 times in the past month
• Expired carbon monoxide level > 8ppm

Where it is running

• Battelle Memorial Institute — Baltimore, Maryland, United States
• University of Vermont — Burlington, Vermont, United States

Full record on ClinicalTrials.gov

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