The Effects of Bariatric Surgeries on Glucose Metabolism
Recruiting now · Early Phase 1
Conditions studied: Post Bariatric Surgery, Gastric Bypass, Sleeve Gastrectomy, Hypoglycemia After Gastric Bypass
In brief
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.
Key facts
- Study ID
- NCT02823665
- Run by
- The University of Texas Health Science Center at San Antonio
- People needed
- 200
- Starts
- 2015-07-01
- Expected to finish
- 2027-08-01
- Last updated by the study team
- 2025-09-09
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Hypoglycemic RYGB patients with documented blood glucose level <50 mg/dl
- Asymptomatic individuals with bariatric surgery
- Healthy non-surgical patients with no personal history of diabetes
- Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center
You may not qualify if…
- Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin <11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies;
- RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea.
- Healthy non-surgical patients with personal history of diabetes
- For administration of atropine, the following exclusions also apply:
- History of glaucoma
- Uncontrolled hypertension (any subjects with BP>140/90 and history of dyslipidemia
- Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)
- Myasthenia gravis
- Brain pathology
- Enlarged prostate in men
Where it is running
- Texas Diabetes Institute - University Health System — San Antonio, Texas, United States (enrolling)
- South Texas Veterans Health Care System — San Antonio, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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