VBMI to Increase Treatment Completion With MK-MK-5172/MK-8742 Among Veterans With Active Substance Use Disorders Genotype 1 Chronic Hepatitis C
Completed · Not applicable
Conditions studied: Patient Adherence, Chronic Hepatitis C, Alcohol-related Disorders
In brief
This study implement a values-based motivational interviewing (VBMI) intervention to promote treatment completion with fixed dose combination (FDC) MK-5172/MK-8742 x 12 weeks among 30 Veterans with substance use disorder (SUD) and treatment naïve genotype 1 chronic hepatitis C virus (HCV) infection.
Key facts
- Study ID
- NCT02823457
- Run by
- G.V. (Sonny) Montgomery VA Medical Center
- People needed
- 20
- Starts
- 2017-04-05
- Expected to finish
- 2020-01-30
- Last updated by the study team
- 2022-01-18
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Identified as having treatment-naïve genotype 1 chronic HCV infection; Veterans who are genotype 1a must have baseline NS5a resistance testing
- Current resident of the SARRTP program
- Willing to initiate treatment with FDC MK-5172/MK-8742 during SARRTP and up to 30 days post-discharge.
- Willing to attend coordinated HCV treatment clinic visits and substance abuse aftercare visits every 2 weeks upon SARRTP discharge
You may not qualify if…
- Contraindications for therapy with FDC MK-5172/MK-8742
- Unable to provide written informed consent
- Hepatocellular carcinoma or other medical condition precluding HCV treatment
- Acute HCV infection
- Prior treatment for chronic HCV
- History of decompensated cirrhosis
- Platelet count < 75 K/cmm and/or albumin < 3 grams/dL
- Females and male sex partners of females who are pregnant, nursing and/or unwilling to use contraception
- Patients infected with genotype 1a who have not undergone baseline NS5a resistance testing
Where it is running
- GV Sonny Montgomery VAMC — Jackson, Mississippi, United States
Full record on ClinicalTrials.gov
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