Effect of Urethral Analgesia on Voiding

Completed · Not applicable · Has a placebo group

Conditions studied: Urethral Analgesia

In brief

The purpose of this study is to evaluate how urethral analgesia impacts voiding efficiency in healthy women. The investigator hypothesizes that anesthetizing the urethral with lidocaine gel will decrease voiding efficiency as measured by standard bladder testing (urodynamic testing).

Key facts

Study ID

NCT02823431

Run by

Duke University

People needed

23

Starts

2016-07-01

Expected to finish

2016-12-01

Last updated by the study team

2018-07-27

Who can join

Age: 18 and older, up to 60. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Females ages 18-60 years
• No health conditions as indicated in exclusion criteria
• Able to provide informed consent and agree to the risks of the study
• Willing to abstain from caffeine and alcohol for 24 hours
• Willing to avoid taking anticholinergic medications (for reasons other than incontinence; e.g., diphenhydramine) for one week prior to the procedure

You may not qualify if…

• Pelvic organ prolapse past the hymen
• Multiple sclerosis, myasthenia gravis, Parkinson's Disease, stroke within the past 6 months
• Interstitial cystitis / Bladder Pain Syndrome
• Recurrent (≥ 3/year) urinary tract infections
• Positive pregnancy test at the time of consent
• ≤ 6 weeks postpartum or if breastfeeding
• Positive urine dip (>+1nitrites or >1+LE) and urinary symptoms at the time of consent
• >1+ blood on urinary dip
• Morbid obesity (BMI >40)
• Taking anticholinergic medications for urinary incontinence
• >2 replies of ≥ "sometimes" on the Lower Urinary Tract Symptoms questionnaire at the time of consent

Where it is running

• Duke University Campus — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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