Enhancing Relapse Prevention for Smoking Cessation With Repetitive Transcranial Magnetic Stimulation

Completed · Not applicable · Has a placebo group

Conditions studied: Smoking Cessation

In brief

Tobacco use is one of the most significant cancer control and public health challenges in the US today. Half of all smokers in the US will attempt to quit tobacco each year, but fully 95% of those who attempt to quit will reverse this decision within 12 months and choose the transient, albeit immediately rewarding activity of smoking at the cost of much larger long-term rewards such as future health and long life. This project seeks to improve scientific knowledge of these decision-making processes and potentially improve the treatment of tobacco dependence by examining the feasibility of using a brain stimulation technique, repetitive Transcranial Magnetic Stimulation or rTMS to improve the efficacy of an existing evidence-based relapse prevention intervention. rTMS is an FDA-cleared treatment for medication resistant depression and is being examined as a treatment for a variety of other disorders. This study will utilize an intensity and duration of rTMS that is well within the safety parameters and similar in location and intensity to that used in previous studies with smokers to reduce cigarette consumption.

Key facts

Study ID

NCT02822703

Run by

The City College of New York

People needed

29

Starts

2015-01-01

Expected to finish

2016-06-01

Last updated by the study team

2016-07-04

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 21-65 years old
• Are fluent in English and be able to read English at the 8th grade level
• Pass the Transcranial Magnetic Stimulation Adult Safety and Screening Questionnaire (TASS)
• Report smoking 5-20 cigarettes daily
• Intend to quit smoking in the next 30 days
• Report a motivation level to quit of ≥7 (scale 0-10)
• Pass a urine drug screen for drugs of abuse (marijuana, cocaine, opioids, amphetamines, etc.)
• No plans to move from the area NYC area in the next 4 months and have a consistent, reliable method of communication so that study staff can successfully contact them

You may not qualify if…

• self-reported claustrophobia
• personal history of epilepsy
• use of anticonvulsant medication
• head injury, aneurysm, stroke, or previous cranial neurosurgery
• diagnosis of major depressive disorder, bipolar disorder, a schizophrenia-spectrum disorder, tinnitus, or migraines
• metal implants in the head, neck, or cochlea; a pacemaker
• currently taking medications that lower seizure threshold (i.e., such as tricyclic antidepressants or bupropion)
• known pre-existing noise induced hearing loss or concurrent treatment of ototoxic medications (i.e., Aminoglycosides, Cisplatine)
• currently using medications for tobacco cessation (i.e., nicotine replacement, bupropion, varenicline, etc.)
• pregnant or planning to become pregnant in the next 12 weeks
• current regular use of forms of tobacco other than cigarettes

Where it is running

• The City College of New York — New York, New York, United States

Full record on ClinicalTrials.gov

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