Delirium, Intraoperative Cerebral Perfusion and EEG Abnormalities After Total Hip Arthroplasty

Stopped early

Conditions studied: Delirium, Hip Arthroplasty, Elderly

In brief

The overall objective of this study is to test for perturbations in intraoperative electroencephalogram (EEG) , cerebral blood flow (CBF), cerebral metabolic rate of oxygen consumption (CMRO2), oxygen extraction fraction (OEF), and serum and cerebral spinal fluid biomarkers associated with delirium in high risk population having elective hip arthroplasty at Penn Presbyterian Medical Center (PPMC).

Key facts

Study ID

NCT02818764

Run by

University of Pennsylvania

People needed

3

Starts

2016-06-01

Expected to finish

2020-12-01

Last updated by the study team

2020-12-23

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients 65 years of age and over scheduled for elective total joint arthroplasty
• Mentally competent and able to give consent for enrollment in the study
• Patients at any age with a pre-existing diagnosis of dementia or acquired cognitive deficit. Consented by legally authorized representative (LAR).

You may not qualify if…

• Patients currently delirious
• Acute neurological disease like stroke or brain tumor
• Current alcohol or substance abuse at risk of postoperative withdrawal

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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