Effectiveness of Light for Enhancement of Cognition by Transcranial Repeated Application (ELECTRA)

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Disease Type and/or Category Not Applicable

In brief

Aim: Investigate whether transcranial photobiomodulation (tPBM) using near-infrared light exposure to the head, can improve frontal lobe executive function, working memory and overall mood in normal volunteer participants. Hypothesis: The investigators predict that tPBM will increase cognitive functioning, as measured by Cambridge Cognition cognitive testing in study subjects.

Key facts

Study ID

NCT02817061

Run by

Massachusetts General Hospital

People needed

80

Starts

2018-03-27

Expected to finish

2019-09-01

Last updated by the study team

2026-03-02

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age: 18-25 or 65-85
• Women of child-bearing potential, must use a double-barrier method for birth control (e.g. condoms with spermicide) if sexually active during the study and for 30 days post treatment of any kind.
• Subject Informed Consent obtained in writing in compliance with local regulations prior to enrollment into this study.
• The subject (and caregiver, if applicable) is willing to participate in this study for at least 12 weeks.

You may not qualify if…

• Inability to speak or read English (necessary for cognitive testing software use).
• Pregnancy or lactation
• History of stroke or traumatic brain injury
• Substance dependence or abuse in the past 6 months
• Diagnosis with major psychiatric disease (Psychotic disorder or psychotic episode, bipolar affective disorder)
• Diagnosed with a neurodevelopmental condition (autism or ADHD)
• A traumatic event that resulted in PTSD
• Any unstable medical illness (defined as any medical illness which has not been well-controlled with standard-of-care medications)
• A significant skin condition (i.e., hemangioma, scleroderma, rash, open wound) or medical implant (e.g. metal plate, implantable shunt or valve) on the head.
• Inability to understand or participate in the consent and performance of the study.
• Those with Parkinson's Disease, End Stage Renal Disease, and/or End Stage Liver Disease

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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