The Hemophilia Ultrasound Project

Stopped early

Conditions studied: Hemophilia A, Hemophilia B

In brief

To evaluate the prevalence of subclinical arthropathy in children with severe hemophilia undergoing a prophylaxis regimen and without evidence of target joints, using a validated ultrasound scoring method.

Key facts

Study ID

NCT02807753

Run by

University of Miami

People needed

18

Starts

2016-09-16

Expected to finish

2020-12-07

Last updated by the study team

2021-01-22

Who can join

Age: any, up to 3. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Severe Hemophilia Cohort:Patients from 0 up to 30 months of age with diagnosis of severe hemophilia A or B defined as a factor VIII:C/IX:C of <1% undergoing prophylaxis regimen with any factor VIII or IX concentrate and without evidence (clinical or by history) of target joint disease.
• Mild/moderate Hemophilia Cohort:Patients from 0 up to 30 months of age with diagnosis of mild hemophilia A or B defined as a factor VIII:C/IX:C of 5-50% and those with diagnosis of moderate hemophilia A or B defined a s a factor VIII:C/IX:C of 1-5% without evidence (clinical or by history) of target joint disease and no history of spontaneous joint bleeds.

You may not qualify if…

• Patients with concomitant Hepatitis B, Hepatitis C and HIV viral infections (because of a recognized arthritogen effect).
• Present or prior history of anti FVIII or IX inhibitors.
• Known inflammatory joint disease.
• Established target joint.

Where it is running

• University of Florida — Gainesville, Florida, United States
• The University of Miami - Department of Pediatrics — Miami, Florida, United States
• University of Kentucky — Lexington, Kentucky, United States
• Tulane — New Orleans, Louisiana, United States

Full record on ClinicalTrials.gov

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