Role of Podocan and Wnt Pathway Regulatory Molecules in Coronary Artery Disease

Completed

Conditions studied: Coronary Artery Disease

In brief

The purpose of this study is to find an association between a protein named Podocan and WNT pathway regulatory molecules in patients with different forms of Coronary Artery Disease (Acute Coronary syndrome, Stable Angina and Coronary Artery Restenosis). It has been found in experimental studies that this protein is regulating smooth muscle cell function and hence may be influencing the progression of Coronary Artery Disease (CAD). We are testing to see if the same regulatory function exists in human subjects. Studying patient's blood will possibly enable to identify an association between Podocan and CAD. This may help to better prevent and treat CAD with improved understanding of the mechanism of the disease. No drugs or other therapeutic interventions will be used for the purpose of the research study. Only blood samples will be collected in the cardiac catheterization lab. As a part of this study participants will be followed for repeat events or repeat cardiac catheterization over a period of 24 months.

Key facts

Study ID

NCT02807714

Run by

Jennifer Victory, RN, CCRC

People needed

571

Starts

2016-06-01

Expected to finish

2020-12-01

Last updated by the study team

2021-02-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 or older
• Scheduled for coronary angiography in the cardiac catheterization lab
• Able to provide informed consent

You may not qualify if…

• Previously enrolled \& sampled in this study

Where it is running

• Bassett Healthcare Network — Cooperstown, New York, United States

Full record on ClinicalTrials.gov

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