A Biomarker-Directed Phase 2 Trial of Tamibarotene (SY-1425) in Participants With Acute Myeloid Leukemia or Myelodysplastic Syndrome
Completed · Phase 2
Conditions studied: Acute Myeloid Leukemia, Myelodysplastic Syndrome
In brief
The purpose of this study is to determine the activity of tamibarotene in participants with relapsed/refractory (R/R) AML (administered as a monotherapy or in combination with azacitidine), R/R higher-risk MDS (HR-MDS) (administered as a monotherapy or in combination with daratumumab), newly diagnosed treatment naïve AML participants who are unlikely to tolerate standard intensive chemotherapy (administered as a monotherapy or in combination with azacitidine), or lower-risk MDS (LR-MDS) (administered as a monotherapy).
Key facts
- Study ID
- NCT02807558
- Run by
- Syros Pharmaceuticals
- People needed
- 155
- Starts
- 2016-09-20
- Expected to finish
- 2023-01-25
- Last updated by the study team
- 2024-12-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Study site — Hartford, Connecticut, United States
- Study site — Miami, Florida, United States
- Study site — Iowa City, Iowa, United States
- Study site — Boston, Massachusetts, United States
- Study site — Ann Arbor, Michigan, United States
- Study site — New York, New York, United States
- Study site — Rochester, New York, United States
- Study site — Durham, North Carolina, United States
- Study site — Cleveland, Ohio, United States
- Study site — Portland, Oregon, United States
- Study site — Allentown, Pennsylvania, United States
- Study site — Pittsburgh, Pennsylvania, United States
- Study site — Nashville, Tennessee, United States
- Study site — Houston, Texas, United States
- CHU Amiens — Amiens, France
- Centre Hospitalier de la Côte basque — Bayonne, France
- Centre Hospitalier Universitiaire Hopital Avicenne — Bobigny, France
- Hospital Morvan — Brest, France
- Centre Hospitalier de Versailles - Hôpital André Mignot — Le Chesnay, France
- Centre hospitalier Lyon Sud — Lyon, France
- Centre Hospitalier Universitaire Nantes — Nantes, France
- Nice Hospital, Archet Hospital 1 Clinical Hematology Service — Nice, France
- Hopital Saint Louis — Paris, France
- Hôpital Haut Leveque, Centre Francois Magendie — Pessac, France
- Centre Hospitalier Universitaire Nancy — Vandœuvre-lès-Nancy, France
Full record on ClinicalTrials.gov
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