Podocan and Wnt Pathway in the Development of Aortopathy in Bicuspid Valve Disease
Completed
Conditions studied: Aortic Valve Disease
In brief
Bicuspid Aortic Valve (BAV) disease is a common cardiac anomaly that is associated with valvular abnormalities, both stenosis and regurgitation, and aortopathy. It is also shown to play role in abnormal aortic distensibility and stiffness with impairment of aortic elasticity and Left ventricular dysfunction. Mechanism of aortopathy is complex and is not understood completely. In a recent study podocan is found in extracellular matrix (ECM) of human aorta and is found to be accumulated in human abdominal aortic aneurysms. There is no current effective therapy that can alter the progression of aortic dilatation in bicuspid valve disease. Aortic surgery and aortoplasty is the only treatment in severely dilated aorta and aortic dissection. In this study the aim is to investigate the association between podocan and Wnt pathway in development and pathogenesis of aortopathy. This could provide more effective and physiological understanding of disease process and potential target in prevention and treatment for aortopathy.
Key facts
- Study ID
- NCT02806310
- Run by
- Bassett Healthcare
- People needed
- 29
- Starts
- 2016-06-01
- Expected to finish
- 2020-12-01
- Last updated by the study team
- 2022-03-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 or greater
- Patients with known BAV diagnosed by echocardiography, previous MRI, or cardiac CT
- Scheduled for cardiac MRI or have had a cardiac MRI within the past year
- Able to provide informed consent
- Ambulatory and expected to be able to complete 6 minute walk test
You may not qualify if…
- Patients without BAV
- Patients who have already had surgery for aortic valve problems and/or aortopathy
- Unable to complete 6 minute walk test (ex. Wheelchair bound)
Where it is running
- Bassett Healthcare Network — Cooperstown, New York, United States
Full record on ClinicalTrials.gov
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