Phase 1/2 Study of Mocetinostat and Durvalumab in Patients With Advanced Solid Tumors and NSCLC

Stopped early · Phase 1/Phase 2

Conditions studied: Advanced Cancer

In brief

Mocetinostat (MGCD0103) is an orally administered HDAC inhibitor. Durvalumab (MEDI4736) is a human monoclonal antibody that is an inhibitor of the Programmed Cell Death Ligand (or PD-L1). Durvalumab is also known as a checkpoint inhibitor. This study is evaluating the combination regimen of mocetinostat and durvalumab in participants with Advanced or Metastatic Solid Tumors and Non-Small Cell Lung Cancer.

Key facts

Study ID

NCT02805660

Run by

Mirati Therapeutics Inc.

People needed

83

Starts

2016-06-01

Expected to finish

2019-12-20

Last updated by the study team

2021-04-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Phase 1-Diagnosis of advanced or metastatic solid tumor; Phase 2-Diagnosis of NSCLC
• Not amenable to treatment with curative intent
• Adequate bone marrow and organ function

You may not qualify if…

• Impaired heart function
• Uncontrolled tumor in the brain
• Other active cancer

Where it is running

• Southern Cancer Center, PC — Mobile, Alabama, United States
• David Geffen School of Medicine at UCLA — Los Angeles, California, United States
• Woodlands Medical Specialists - Pensacola — Pensacola, Florida, United States
• Robert H. Lurie Comprehensive Cancer Center of Northwestern University — Chicago, Illinois, United States
• NorthShore University Health System — Evanston, Illinois, United States
• Unniversity of Minnesota Masonic Cancer Center — Minneapolis, Minnesota, United States
• Hackensack University Medical Center — Hackensack, New Jersey, United States
• Montefiore Medical Center — The Bronx, New York, United States
• Sarah Cannon Research Institute — Nashville, Tennessee, United States
• Mary Crowley Cancer Research Centers — Dallas, Texas, United States
• Texas Oncology - Denton South — Denton, Texas, United States
• Texas Oncology-Plano West — Plano, Texas, United States
• Virginia Cancer Specialists — Fairfax, Virginia, United States
• Shenandoah Oncology - Winchester — Winchester, Virginia, United States
• Seattle Cancer Care Alliance — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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