The Impact of a Known Bioactive Agent on the Resolution of Alveolar Socket Preservation
Withdrawn before enrolling · Not applicable
Conditions studied: Healing of Extraction Socket
In brief
The advent of endosseous implant restoration has driven an increasing need for alveolar bone preservation and/or augmentation strategies. Investigations have explored the physical scaffold effects of a wide variety of bone graft materials with each graft material offering a more or less attractive surface for bone deposition. The seeding of these scaffolds with biologically active material seeks to enhance the "osteoconductive" effect by influencing the temporal or sequential steps which result in the desired end product-new bone. Alveolar socket grafts are a common example of these preservation techniques. They are an accepted procedure to maximize the retention of alveolar bone post extraction. They appear to act as a passive scaffold for clot retention and subsequent bone regeneration. The current pilot research project explores addition of a known Bioactive Agent: Platelet Derived Growth Factor (PDGF) to test its impact on healing responses. Histomorphometric assessments will be utilized on microscopic slide material derived from cores trephined as the initial step in the preparation for placement of endosseous dental implants. Outcomes measured will include: Clinical observation of healing response Microscopic measures will be * Measures of residual graft material * New bone formation and new bone contact area with graft * Measures of vascular content * Osteoclast count * Qualitative measures of other marrow components (Cells and relative fiber/ fat content, liner cell characteristics.)
Key facts
- Study ID
- NCT02802436
- Run by
- Boston University
- People needed
- 0
- Starts
- 2016-10-03
- Expected to finish
- 2018-07-01
- Last updated by the study team
- 2018-07-05
Who can join
Age: 20 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients will be selected from the pool of periodontal patients at BUSDM (Boston University School of Dental Medicine) who have been treatment planned for at least two extractions which will be atleast one tooth apart in either arch (maxilla or mandible) followed by delayed 3-4 months dental implant placement.
- Subjects will be in age group 20-80 years of age.
You may not qualify if…
- Patients with known systemic disorders affecting bone Example - Osteoporosis, Diabetes Mellitus, Hyperthyroidism, Arthritis, smokers and pregnant women will be excluded.
- Untreated acute infections at the surgical site
- Untreated malignant neoplasm(s) at the surgical site
- Patients with a known hypersensitivity to any product component (ß-TCP = Tri calcium phosphate or rhPDGF-BB = Platelet derived growth factor)
Where it is running
- Henry M. Goldman School of Dental Medicine, Boston University — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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