Using MOST to Optimize an HIV Care Continuum Intervention for Vulnerable Populations

Completed · Not applicable

Conditions studied: HIV

In brief

The present study targets the large population of persons living with HIV/AIDS (PLHA) in the U.S. who are both insufficiently engaged in HIV primary care and not taking antiretroviral therapy (ART), who are mainly African American/Black and Latino. NIH has emphasized the urgent need for new research approaches to advance intervention science, and the proposed project employs a new, potent, and innovative research methodology, the Multiphase Optimization STrategy (MOST), a framework for developing highly efficacious, efficient, scalable, and cost-effective interventions. The proposed study has the highest public health significance: it addresses a vulnerable population of PLHA, including the critically important subpopulations of men who have sex with men (MSM) and substance users; will develop an efficient and cost effective intervention to increase engagement along the HIV care continuum for these vulnerable groups; and addresses two areas highlighted in the August 2015 notice on research priorities from the NIH Office of AIDS Research (NOT-OD-15-137), namely, engaging PLHA in prevention/treatment services, and reducing HIV/AIDS-related racial/ethnic disparities.

Key facts

Study ID

NCT02801747

Run by

New York University

People needed

512

Starts

2017-03-20

Expected to finish

2022-07-15

Last updated by the study team

2022-11-03

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• African American/Black or Latino/Hispanic race/ethnicity
• HIV diagnosed for at least 6 months (HIV status confirmed with medical documentation)
• Has not taken antiretroviral therapy (ART) in the past 6 weeks (the period of time assessed by hair assay, and a reasonable period of time not on ART for the present study)
• Sub-optimal engagement in HIV care (assessed from the medical record, defined as less than 1 visit in every 4-mo. period in the past year [two of them at least 90 days apart], pro-rated for those diagnosed less than a year ago) or > 2 missed visits (without prior cancellation) in the past year
• Reside in the New York City (NYC) metropolitan area
• Not planning to leave the NYC metropolitan area in next year
• Not actively psychotic based on screening instrument
• Not a participant in the preliminary pilot HTH R34 study
• Able to conduct research activities in English or Spanish
• Willing to provide hair sample (if possible), blood samples (to assess CD4, VL), and Medical Report Form ([MRF]; to assess health care attendance) at screening
• Willing to participate in a Core intervention session and be randomly assigned to 1-5 intervention components.

You may not qualify if…

• NONE SEE ABOVE

Where it is running

• New York University Silver School of Social Work — New York, New York, United States

Full record on ClinicalTrials.gov

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