The Impact of Reward-induced Dopamine Release on Functional Connectivity: a Combined PET/fMRI Study

Completed

Conditions studied: Healthy

In brief

The present study would be the first to investigate the relationship between reward- and or social stimuli-induced dopamine (DA) release and neural function using a combined PET/fMRI approach. Data from this project conducted in healthy subjects will provide preliminary data for a larger grant application to study patient populations with known abnormalities in DA including schizophrenia, major depressive, substance use, and eating disorders.

Key facts

Study ID

NCT02801643

Run by

Stony Brook University

People needed

5

Starts

2016-06-01

Expected to finish

2017-12-01

Last updated by the study team

2018-04-17

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy men and women age 18-45 who have the capacity to consent to the protocol.
• Ability to understand and follow instructions and oriented to name, time, and place.
• A negative urine pregnancy and toxicology screen
• Willingness to abstain from using aspirin, NSAIDs, or anticoagulants during the study

You may not qualify if…

• Left-handed or ambidextrous
• History of seizures
• History of strokes
• Clinically significant, uncontrolled liver, kidney, cardiac, or pulmonary disease
• Terminal medical diagnosis consistent with survival < 1 year
• Serious mental impairment. Mini mental state exam of < 23/30
• Current or past DSM-IV Axis I or neurologic disorders
• Actively abusing substances, including alcohol (regular alcohol use during the past 6 months equal to or greater than 16 cans of beer per week or equivalent; use of street drugs or regular tobacco use during the past 6 months)
• Unstable medical condition (≥ 3 months), or serious medical illnesses during the past three months (e.g., serious infections)
• Unexplained loss of consciousness; history of traumatic brain injury involving loss of consciousness greater than 2 minutes
• Currently pregnant or breastfeeding, sexually active and of child-bearing potential and not using adequate contraceptive methods
• Childbirth or miscarriage during past 6 months, breastfeeding within 6 months of recruitment
• Allergic to latex and/or study pharmaceuticals
• Diabetes and/or unable to fast for up to 7 hours
• Unable to lie comfortably in the scanner for up to 4 consecutive hours
• Would receive a total of over 5 rems to a radiosensitive organ (bone marrow, gonads, lens of the eye) or 15 rems to any other organ or to the body as a whole during a 12 month period
• Contraindications for MRI including neurostimulators, implanted medical devices, metal in the body, claustrophobia, weight over 440 pounds, and girth size incompatible for scanner bore.
• Participation in a similar Social Feedback Task within 2 months of the start of the study.

Where it is running

• Health Sciences Center — Stony Brook, New York, United States

Full record on ClinicalTrials.gov

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