Late Permissive Hypercapnia for Intubated and Ventilated Preterm Infants

Completed · Not applicable

Conditions studied: Premature Neonate

In brief

Preterm infants, less than 37 weeks gestation with respiratory distress syndrome, who remain ventilated between 7 and 14 days after birth will be randomized to a ventilator strategy of either a higher level of permissive hypercapnia or of a lower level of permissive hypercapnia to determine if either strategy will increase the number of alive ventilator-free days in the 28 days after randomization.

Key facts

Study ID

NCT02799875

Run by

University of Alabama at Birmingham

People needed

130

Starts

2015-12-01

Expected to finish

2021-04-01

Last updated by the study team

2021-05-03

Who can join

Age: 0 and older, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Gestational age at least 22 but less than 37 weeks;
• Intubated on mechanical ventilation for respiratory distress syndrome on days 7-14 after birth;
• Admitted to Neonatal Intensive Care Unit before 7 days after birth;
• Informed consent per parent(s)

You may not qualify if…

• Major malformation
• Neuromuscular condition that affects respiration
• Terminal illness
• Attending physician has made a decision to withhold or limit support for the infant

Where it is running

• UAB — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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