Genomic Translation for Amyotrophic Lateral Sclerosis Care
Completed
Conditions studied: ALS
In brief
The purpose of this study is to look for abnormal genes and gene expression profiles that help determine why a person develops amyotrophic lateral sclerosis (ALS) and related motor neuron diseases (MND) and why their symptoms present and progress with a particular pattern.
Key facts
- Study ID
- NCT02795897
- Run by
- Columbia University
- People needed
- 254
- Starts
- 2016-06-08
- Expected to finish
- 2022-06-29
- Last updated by the study team
- 2022-08-19
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Study participants meeting all of the following criteria will be eligible for enrollment in GTAC:
- Men or women of any race or ethnicity aged 18 or older
- Diagnosis of familial or sporadic ALS (definite, probable, or possible according to El Escorial Criteria, Appendix 1), or those with primary lateral sclerosis or progressive bulbar/muscular atrophy forms of motor neuron disease. All-comers with ALS/MND should be enrolled without regard to familial vs sporadic or gene mutation status (i.e. participants with known gene mutations should still be enrolled), or phenotype.
- Capable of providing informed consent and following study procedures (in the case that a subject lacks the ability to provide informed consent, informed consent will be sought from the subject's surrogate representative).
- Willing to return to clinic site (or another participating center) for follow-up care.
You may not qualify if…
- Study participants meeting any of the following criteria during screening evaluation will be excluded from enrolling in GTAC:
- Invasive ventilation (i.e. tracheostomy) in place.
- Non-invasive ventilation dependent (defined as >22 hours per day)
- Pregnancy.
- Known Human Immunodeficiency Virus (HIV) , chronic Hepatitis B, or Hepatitis C (because cells will be frozen down for future cell line generation).
Where it is running
- Cedar Sinai Medical Center — Los Angeles, California, United States
- University of Colorado School of Medicine — Aurora, Colorado, United States
- Univeristy of Michigan — Ann Arbor, Michigan, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- Washington University — St Louis, Missouri, United States
- Columbia University — New York, New York, United States
- Duke University — Durham, North Carolina, United States
- Oregon Health & Sciences University — Portland, Oregon, United States
- Penn State College of Medicine — Hershey, Pennsylvania, United States
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
- Houston Methodist Neurological Institute — Houston, Texas, United States
- University of Utah — Salt Lake City, Utah, United States
- University of Washington — Seattle, Washington, United States
- The University of Edinburgh — Edinburgh, United Kingdom
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.