Follow up 18F-AV-1451 Scan in Confirmatory Cohort Subjects From Study 18F-AV-1451-A05

Completed · Phase 2

Conditions studied: Alzheimer's Disease

In brief

This study will evaluate longitudinal change of tau deposition as measured by flortaucipir F 18 uptake over time.

Key facts

Study ID

NCT02795780

Run by

Avid Radiopharmaceuticals

People needed

79

Starts

2016-08-01

Expected to finish

2017-08-28

Last updated by the study team

2020-08-24

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmatory cohort subjects who completed the 18F-AV-1451-A05 (NCT02016560) study

You may not qualify if…

• Current clinically significant cardiovascular disease, ECG abnormalities, risk factors for Torsades de Pointes (TdP), or are taking drugs known to cause QT prolongation
• Current clinically significant infectious disease, endocrine or metabolic disease, pulmonary, renal or hepatic impairment, or cancer
• Females of childbearing potential who are not surgically sterile, not refraining from sexual activity or not using reliable methods of contraception
• Have had a non-study related radiopharmaceutical imaging or treatment procedure within 7 days prior to the study imaging session
• Have received or participated in a trial with investigational medications in the past 30 days

Where it is running

• Banner Alzheimer's Institute — Phoenix, Arizona, United States
• Imaging Endpoints — Scottsdale, Arizona, United States
• Mayo Clinic Arizona — Scottsdale, Arizona, United States
• Banner Sun Health Research Institute — Sun City, Arizona, United States
• Institute for Brain Aging and Dementia, UC Irvine — Irvine, California, United States
• 21st Century Oncology — Newport Beach, California, United States
• Alzheimer's Disease Center, UC Davis — Sacramento, California, United States
• California Medical Clinic for Headache — Santa Monica, California, United States
• Neuropsychiatric Research Center of Southwest Florida — Fort Myers, Florida, United States
• Compass Research, LLC — Orlando, Florida, United States
• Meridien Research — St. Petersburg, Florida, United States
• University of South Florida Health Byrd Alzheimer's Institute — Tampa, Florida, United States
• Premiere Research Institute — West Palm Beach, Florida, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Boston University School of Medicine — Boston, Massachusetts, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Las Vegas Radiology — Las Vegas, Nevada, United States
• New York University Center for Brain Health — New York, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Rhode Island Hospital — Providence, Rhode Island, United States
• Butler Hospital — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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