Genetic Study of Families With High Frequency of Hodgkin Lymphoma

Completed

Conditions studied: Hodgkin Lymphoma

In brief

Hodgkin lymphoma (HL) is a relatively rare disorder with known familiar aggregation (i.e. HL in more than one child, or parent and child). Because affected individuals in familial HL are genetically related, the existence of such families has long been considered as evidence in support of a genetic basis of HL susceptibility. However, it is largely unknown which genetic variations are responsible for recurring HL in families. Because the effects of genetic variants are likely to be strong in familial HL, identification of such variations will potentially reveal biological pathways critical to the pathogenesis of HL. PRIMARY OBJECTIVE: * To perform genome-wide sequencing of families with recurring Hodgkin lymphoma cases (affected as well as non-affected family members) to identify potential disease-causing germline genetic variations. SECONDARY OBJECTIVE: * To describe demographic and clinical features of the affected families.

Key facts

Study ID: NCT02795013
Run by: St. Jude Children's Research Hospital
People needed: 27
Starts: 2016-08-17
Expected to finish: 2018-02-27
Last updated by the study team: 2018-09-13

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patient with HL diagnosed ≤ 21 years of age with a first-degree relative also diagnosed with HL.
Family members of the patient, either affected or unaffected by a malignancy who agree to participate in the study.
Research participant or legal guardian, as appropriate, must provide informed consent for this protocol.

You may not qualify if…

Inability or unwillingness of research participant or legal guardian/representative to give written informed consent.

Where it is running

St. Jude Children's Research Hospital — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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