Descriptive Analysis of Gut Microbiome Alterations in Hyperoxaluric Patients

Status unconfirmed

Conditions studied: Oxalate, Primary Hyperoxaluria, Microbiome

In brief

To characterize the microbiome in 4 groups of subjects (primary hyperoxaluria type I (PH1), idiopathic CaOx stone, enteric hyperoxaluria (EH) and healthy participants) by comparing the number of species and diversity of the microbial populations and pathway for oxalate metabolism by paralleling the gene expression of enzymes involved in oxalate degradation by gut bacteria.

Key facts

Study ID

NCT02794649

Run by

VA New York Harbor Healthcare System

People needed

60

Starts

2016-06-01

Expected to finish

2018-06-01

Last updated by the study team

2017-09-26

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Primary hyperoxaluria: Patients diagnosed with type I PH by genetic testing and part of the Rare Kidney Stone Consortium (RKSC) Primary hyperoxaluria registry
• Enteric hyperoxaluria: Patients with Roux-en-Y-gastric-bypass
• Idiopathic CaOx stone : History of passing or having surgically removed a calcium oxalate kidney stone within 5 years of recruitment
• Healthy participants with no history of kidney or bowel disease

You may not qualify if…

• History of kidney or liver transplant
• History of antibiotics use within 6 months of recruitment

Where it is running

• New York University School of Medicine — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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