Mitochondrial Activity of Cumulus Cells From the Cumulus-oocyte Complex and Oocyte Competence
Completed
Conditions studied: Infertility
In brief
The need for non-invasive biomarkers of oocyte competency has become urgent as women increasingly delay attempts at childbearing. The aging process is complex and includes impaired mitochondrial dysfunction, oxidative stress, diminished metabolic activity, and activity of several cell-signaling systems. Cumulus cells form an intimate association with the oocyte in the follicle, and they can have a significant impact on oocyte meiotic and developmental competence. In the IVF lab, the clump of cumulus cells is typically cut away from the oocyte immediately after an oocyte retrieval procedure, and then the cumulus cells are discarded. Measuring the mitochondrial respiratory activity of cumulus cells may serve as a non-invasive biomarker for oocyte competency and a predictor of reproductive success in IVF patients in the future.
Key facts
- Study ID
- NCT02793752
- Run by
- Main Line Fertility Center
- People needed
- 100
- Starts
- 2016-03-01
- Expected to finish
- 2017-03-01
- Last updated by the study team
- 2020-08-11
Who can join
Age: 21 and older, up to 42. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Patients undergoing IVF in an attempt to achieve pregnancy.
- Day 3 FSH < 10 IU/ml, LH< 12 IU/ml, and estradiol <50 pg/ml on day 2-4 of menstrual cycle
- Antimullerian Hormone > 1.5 and < 10
- Between 10 and 20 basal antral follicles on day 2-4 of the menstrual cycle
- Body weight >50 kg, with BMI > 18 and < 32 kg/m2
You may not qualify if…
- Smokers
- Polycystic ovarian disease
- Endometriosis greater than Stage I
- Testicular or Epididymal Sperm
- PGD/PGS
Where it is running
- Main Line Fertility Center — Bryn Mawr, Pennsylvania, United States
Full record on ClinicalTrials.gov
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