Dexamethasone and Post-tonsillectomy Pain in Children

Completed · Phase 4 · Has a placebo group

Conditions studied: Pediatric Post-tonsillectomy Pain

In brief

The investigators will use a prospective randomized, controlled design utilizing a single preoperative dose of oral dexamethasone or placebo to achieve these specific aims: * Specific Aim 1: To evaluate the potential for a single preoperative dose of oral dexamethasone administered the night before surgery to reduce the incidence and severity of early post tonsillectomy pain (PTP) in children * Specific Aim 2: To prospectively evaluate differences in early PTP experience between overweight/obese children and their lean peers. * Specific Aim 3: To determine whether circulating inflammatory markers are strongly linked to PTP severity in children and whether they could be potential contributors to the higher pain experienced by overweight/obese children following Tonsillectomy and or Adenoidectomy.

Key facts

Study ID

NCT02793011

Run by

Nationwide Children's Hospital

People needed

137

Starts

2016-06-01

Expected to finish

2019-06-27

Last updated by the study team

2020-09-10

Who can join

Age: 4 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Scheduled for tonsillectomy and/or adenoidectomy at University of Michigan, C. S. Mott Children's Hospital

You may not qualify if…

• Known hypersensitivity to dexamethasone
• Developmental delay
• Taking chronic analgesics
• Taking chronic systemic steroids
• Treatment with steroids in last 30 days
• Cushings or Prader-Willi or Nephrotic Syndromes
• Diabetes Mellitus

Where it is running

• University of Michigan C.S. Mott Children's Hospital — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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