A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection
Running, not enrolling · Phase 2
Conditions studied: Craniopharyngioma
In brief
Craniopharyngioma is a rare brain tumor that affects both children and adults. It arises in a region of the brain near the pituitary gland, visual pathways, and central blood vessels. Patients often present with headache, loss of vision or delayed growth. In some instances they may present with imbalance of water and salts in the body. The treatment for craniopharyngioma may be radical surgery or a combination of surgery and radiation therapy. In some instances surgery is not required. If the tumor cannot be completely removed, radiation therapy may be required. In this study we will use the most advanced form of proton therapy which is called intensity-modulated proton therapy. This is a newer form of radiation therapy which has a number of advantages over older forms of proton therapy and conventional radiation therapy using x-rays. The main goal of this study is to learn if proton therapy will effectively treat patients with craniopharyngioma brain tumors and reduce side effects compared to more traditional forms of radiation therapy.
Key facts
- Study ID
- NCT02792582
- Run by
- St. Jude Children's Research Hospital
- People needed
- 160
- Starts
- 2016-06-22
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-06-17
Who can join
Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Craniopharyngioma diagnosed by histology, cytology or neuroimaging or intra-operative assessment
- Patients ages 0-21 years at the time of diagnosis
You may not qualify if…
- Prior history of fractionated radiation therapy
- Prior treatment with intracystic P-32 or intracystic bleomycin
- Pregnant females are excluded. Radiation has teratogenic or abortifacient effects
Where it is running
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States
Full record on ClinicalTrials.gov
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