Evaluation of [18F]RO6958948 as Tracer for Positron Emission Tomography (PET) Imaging of Tau Burden in Alzheimer's Disease Participants

Completed · Phase 1

Conditions studied: Alzheimer's Disease

In brief

This is a longitudinal, follow-up study in participants with Alzheimer's disease (AD) who previously participated in study BP29409 (NCT02187627). This study is designed to assess the longitudinal change of Tau pathology in the brain of participants with AD using the PET ligand \[18F\]RO6958948 and to assess the safety and tolerability of PET ligand.

Key facts

Study ID: NCT02792179
Run by: Hoffmann-La Roche
People needed: 4
Starts: 2016-07-19
Expected to finish: 2016-09-28
Last updated by the study team: 2017-11-01

Who can join

Age: 25 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

AD participants previously scanned with [18F]RO6958948 in Roche Study BP29409
Agreement to use highly effective contraception measures
Body mass index (BMI) between 18 and 32 Kilograms per square meter (kg/m\^2)
A study partner able to accompany the participant to all visits and answer questions about the participant
In the opinion of investigator, based on the medical history and physical examination, can safely tolerate tracer administration and the scanning procedures
Documented positive visual read (as per local procedures for florbetapir or similar procedures for other amyloid tracers) of an amyloid PET scan, which in the opinion of the principal investigator is consistent with a diagnosis of AD

You may not qualify if…

Exclusion Criteria for All Participants
History or presence of any clinically relevant hematological, hepatic, respiratory, cardiovascular, renal, metabolic, endocrine, or central nervous system disease or other medical conditions that are not well controlled, may put the participant at risk, could interfere with the objectives of the study, or make the participant unsuitable for participation in the study for any other reason in the opinion of the principal investigator
Clinically relevant pathological findings in physical examination, electrocardiogram, or laboratory values at the screening assessment that could impact participant safety
Known history of clinically significant infectious disease including autoimmune deficiency syndrome (AIDS) or serological indication of acute/chronic hepatitis B or C or Human Immuno Virus infection
Women of childbearing potential must not be pregnant, or nursing and serum human chorionic gonadotropin (HCG) must be negative at the time of Screening Visit 1, and urine HCG must be negative on all subsequent visits
Loss or donation of more than 450 milliliters (mL) blood in the 4 months before screening or donation of plasma within 14 days of screening
Unsuitable veins for repeated venipuncture
History of drug or alcohol abuse or positive result from urine screen for drugs of abuse
Have received an investigational medication within the last 3 months or 5 times the elimination half-life, whichever is longer, prior to enrollment Exclusion Criteria Related to Trial Procedures
Has had or is planning to have exposure to ionizing radiation that in combination with the study-related tracer administrations and scanning procedures would result in a cumulative exposure that exceeds the recommended annual exposure limit
Presence of pacemakers; aneurysm clips; artificial heart valves; ear implants; foreign metal objects in the eyes, skin, or body, or any other circumstance that would contraindicate a magnetic resonance imaging (MRI) scan
History of, or suffers from, claustrophobia or feels that he or she will be unable to lie still on their back in the MRI or PET scanner
Has received treatment that targeted amyloid-beta or tau within the last 24 months

Where it is running

Johns Hopkins Medical Institutions, Johns Hopkins Outpatient Center — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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