Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People
Recruiting now
Conditions studied: Myocardial Infarction
In brief
A prospective cohort of relatively healthy individuals, using comprehensive clinical information, advanced imaging (including cardiac MRI), cardiovascular exercise physiology, metabolomics and genetic analysis. These findings will be correlated with adverse clinical outcomes including death, stroke and myocardial infarction. In selected cases, follow-up imaging and biomarker samples will also be obtained. These studies will enable us to begin to address a critical gap in our knowledge as to how best to interpret the very large amount of cardiovascular tests done in Singapore and how to better to predict outcomes and manage healthcare costs in our local populations
Key facts
- Study ID
- NCT02791152
- Run by
- National Heart Centre Singapore
- People needed
- 1000
- Starts
- 2015-10-01
- Expected to finish
- 2036-12-01
- Last updated by the study team
- 2016-06-06
Who can join
Age: 21 and older, up to 69. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women age 21-69 years
You may not qualify if…
- Previous myocardial infarction (MI). This will include ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI)
- Known coronary artery disease - prior coronary revascularization
- Known documented peripheral arterial disease
- Previous stroke
- a. Stroke is defined as new focal neurological deficit persisting more than 24hours21.
- More than ongoing use of 2 or more anti-hypertensive agents
- Prior history of cancer (excludes pre-cancerous lesions)
- Expected life expectancy less than 1 year
- Known definite diabetes mellitus or on treatment for diabetes mellitus
- Known autoimmune disease or genetic disease
- Known endocrine disease on treatment
- Psychiatric illness
- Asthma or chronic lung disease requiring long term medications or oxygen
- Chronic infective disease, including tuberculosis, hepatitis B and C; and HIV
- Inability to comply with study protocol
- Any other acute or chronic medical or physical condition deemed by the investigator to affect study outcomes
Where it is running
- National Heart Centre Singapore — Singapore, Singapore, Singapore (enrolling)
Full record on ClinicalTrials.gov
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