Phase 2 Study With SNF472 in Calciphylaxis Patients

Completed · Phase 2

Conditions studied: Calciphylaxis, Calcific Uremic Arteriolopathy

In brief

To evaluate the effect of SNF472 on top of standard of care on promoting wound healing and other parameters of therapeutic response in haemodialysis patients with calciphylaxis (calcific uraemic arteriolopathy, CUA).

Key facts

Study ID

NCT02790073

Run by

Sanifit Therapeutics S. A.

People needed

14

Starts

2016-05-01

Expected to finish

2017-11-15

Last updated by the study team

2019-08-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with either newly diagnosed CUA OR recurrent CUA that has been dormant with no skin lesion involvement for at least 90 days from study start (new or recurrent diagnosis must be made within 5 weeks of study start)
• Patients who signed the written informed consent to participate in this clinical trial (prior to any clinical trial-related procedures being performed), after reading the Patient Information Sheet and Informed Consent Form (ICF), and who had the opportunity to discuss the clinical trial with the Investigator or designee
• Males or females aged ≥18
• Patients on maintenance haemodialysis (HD)
• Patients with at least a minimum level of pain on Visual Analog Scale (VAS) scale or on pain-killers stronger than non-steroidal anti-inflammatory drugs (NSAIDs)
• Females of child-bearing potential should use a highly effective contraceptive measure throughout the study and have a negative serum pregnancy test at entry. Male patients having sexual relationship in which pregnancy can occur should take adequate contraceptive precautions (wear a condom)

You may not qualify if…

• Body weight above 150 kg
• BMI >35 and central(abdominal) ulcers
• History of bisphosphonate treatment within 12 months before entering into the study
• Severely ill patients without reasonable expectation of survival for > 6 months according to the treating physician
• Patients with scheduled parathyroidectomy during the run-in or study period
• Female patients who are either intending to get pregnant or are undergoing treatment to get pregnant, as well as breast-feeding females
• Participation in another clinical trial with an experimental drug within 90 days prior the inclusion
• Any psychological, emotional problems, any disorders or resultant therapy that is likely to invalidate informed consent, or limit the ability of the patient to comply with the Clinical Trial Protocol requirements
• Patients who, in the opinion of the Investigator, are considered unsuitable for any other reason

Where it is running

• Fresenius Medical Services — Waltham, Massachusetts, United States
• Davita Clinical Research — Minneapolis, Minnesota, United States
• Salford Royal Hospital — Salford, United Kingdom

Full record on ClinicalTrials.gov

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