Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery

Completed · Not applicable

Conditions studied: Analgesia, Obstetrical, Obstetric Surgical Procedures

In brief

Intrathecal (IT) opioids are commonly administered with local anesthetic during spinal anesthesia for post-Cesarean delivery analgesia. Traditionally, IT morphine has been used but the use of IT hydromorphone is growing. A previous study has shown that the effective dose for postoperative analgesia in 90% patients (ED90) for both IT hydromorphone and IT morphine (NCT02009722). These doses were found to be 75 mcg for hydromorphone and 150 mcg for morphine. The current proposed study would compare the duration of analgesia of IT morphine vs IT hydromorphone after elective cesarean delivery. Additionally, the investigators will compare each drug with respect the incidence of nausea and pruritus.

Key facts

Study ID

NCT02789410

Run by

Mayo Clinic

People needed

134

Starts

2016-05-01

Expected to finish

2018-03-15

Last updated by the study team

2019-04-25

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• American Society of Anesthesiologists (ASA) physical status II-III women presenting for elective cesarean delivery
• Term gestation (37-42 weeks)
• Desire to have a spinal anesthesia technique for cesarean delivery

You may not qualify if…

• Any contraindication to the administration of a spinal technique for anesthesia
• History of intolerance or adverse reaction to opioid medications
• Chronic pain syndrome or current opioid use >30 oral morphine equivalents/day
• Allergy or intolerance to acetaminophen, ketorolac, ibuprofen, or oxycodone
• Current BMI > 50

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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