Helicobacter Pylori Genome Project (HpGP)
Stopped early
Conditions studied: Gastric Cancer, Non-Atrophic Gastritis, Intestinal Metaplasia
In brief
Helicobacter pylori is a common bacterial infection. It can lead to severe stomach problems, including stomach cancer. Researchers want to look at samples of the bacteria. These H. pylori strains will be taken from chronically infected people. They want to identify the genetic and epigenetic differences in H. pylori strains. This could help predict which people who get infected with the bacteria will get stomach cancer. This could lead to the cancer being detected earlier. It could also mean less people get stomach cancer. Objectives: To study genetic variations of H. pylori strains based on samples from chronically infected people. To identify the features of strains that might lead to severe stomach problems or stomach cancer. Eligibility: People ages 30-70 years who need an upper endoscopy or who were recently diagnosed with stomach cancer Design: Participants will be screened by the doctor who does their procedure and a study nurse. Participants who have endoscopy will have \~6 biopsies removed. These are tissue samples. They are about the size of a grain of rice. Participants will allow the study team to access reports from their stomach exam. Participants with stomach cancer will donate some of the tissue that will be removed during their clinical care. They will allow the study team to access reports of their surgery. They will also allow them to access the microscope slides of their stomach.
Key facts
- Study ID
- NCT02788214
- Run by
- National Cancer Institute (NCI)
- People needed
- 1000
- Starts
- 2016-07-27
- Expected to finish
- 2020-05-15
- Last updated by the study team
- 2020-12-19
Who can join
Age: 30 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- H. pylori strains collected from:
- Adult aged 30 to 70 years old.
- Patients who need upper endoscopy (examination of the lining of their stomach with a flexible tube).
- Patients with stomach cancer.
Where it is running
- Stanford University — Stanford, California, United States
- Georgia Cancer Center Biorepository — Athens, Georgia, United States
- Centers for Disease Control and Prevention — Atlanta, Georgia, United States
- Albert Einstein College of Medicine — The Bronx, New York, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- Baylor College of Medicine — Houston, Texas, United States
- Université Ferhat Abbas — Sétif, Algeria
- Hospital Alemán — Buenos Aires, Argentina
- Dhaka Medical College and Hospital — Dhaka, Bangladesh
- Ghent University — Ghent, Belgium
- Universidade Federal de Minas Gerais — Belo Horizonte, Brazil
- AC Camargo Cancer Center — São Paulo, Brazil
- Medical University of Sofia — Sofia, Bulgaria
- Tsaritsa Yoanna University Hospital — Sofia, Bulgaria
- Defence Services General Hospital — Yangon, Burma
- University of Dschang — Dschang, Cameroon
- University of Alberta — Edmonton, Canada
- Universidad de Concepción — Concepción, Chile
- Hospital Hanga Roa — Easter Island, Chile
- Pontificia Universidad Catolica — Santiago, Chile
- Instituto Nacional de Cancerología — Bogotá, Colombia
- Universidad del Valle — Cali, Colombia
- Universidad de Nariño — Pasto, Colombia
- Universidad de Costa Rica — San José, Costa Rica
- White River Medical Center — Batesville, Arkansas, United States
Full record on ClinicalTrials.gov
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