Volixibat (SHP626) in the Treatment of Adults With Nonalcoholic Steatohepatitis (NASH)

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Non-Alcoholic Steatohepatitis

In brief

The purpose of this study is to determine if the investigational treatment volixibat (SHP626) is safe, tolerable and effective in adults with nonalcoholic steatohepatitis (NASH).

Key facts

Study ID

NCT02787304

Run by

Mirum Pharmaceuticals, Inc.

People needed

197

Starts

2016-10-24

Expected to finish

2018-07-27

Last updated by the study team

2019-11-25

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• An understanding, ability, and willingness to fully comply with study procedures and restrictions.
• Ability to voluntarily provide written, signed, and dated (personally or via a legally authorized representative, as applicable) informed consent to participate in the study.
• Age 18-80 years inclusive. This inclusion criterion will only be assessed at the first screening visit.
• Male, or non-pregnant, non-lactating female, who is sexually active and who agrees to comply with the contraceptive requirements of the protocol, or females of non-childbearing potential. Males and females of child-bearing potential who are sexually active must agree to use acceptable contraception during the study and for 30 days following the last dose of the investigational product (IP).
• Presence of greater than equals to (>=) 5 percent (%) steatosis on screening magnetic resonance imaging (MRI) from a centrally read radiologist performed either during the screening period or within 6 months prior to the first visit.
• Histologic confirmation of nonalcoholic steatohepatitis (NASH) without cirrhosis (F0-F3) from a centrally read liver biopsy performed either during the screening period or within 6 months prior to the first visit with a NAS of >=4 with a score of at least 1 in each component (steatosis, lobular inflammation, and hepatocyte ballooning).

You may not qualify if…

• Presence of or history of cirrhosis or evidence of decompensated liver disease (example: ascites, variceal bleeding, etc.) or hepatocellular carcinoma.
• History or presence of other concomitant liver disease as assessed by the investigator or determined by laboratory findings including, but not limited to: active hepatitis B virus (HBV) infection (hepatitis B surface antigen [HBsAg] positive and/or hepatitis B virus deoxyribonucleic acid (HBVDNA) positive; subjects who are hepatitis B core antibody [HBcAb] positive may be eligible as long as HBsAg is negative and HBVDNA is non detectable), active hepatitis C virus (HCV) infection (prior exposure to HCV [defined as HCVAb positive] without a current or prior history of a detectable HCVRNA) may be eligible, alcoholic liver disease, proven autoimmune hepatitis, primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), hemochromatosis, Wilson's disease, alpha-1 antitrypsin deficiency, bile duct obstruction, liver primary or metastatic cancer.
• Current or recurrent disease that could affect the action, absorption, disposition, or laboratory assessment of the IP (including bile salt metabolism in the intestine) example (e.g,) uncontrolled inflammatory bowel disease, uncontrolled celiac disease, gastric bypass procedures (gastric lap band or gastric sleeve is acceptable), ileal or ileocecal resection, uncontrolled irritable bowel syndrome with predominant diarrhea, or history of chronic diarrhea or loose stools of any etiology.
• Weight change >=5% after qualifying liver biopsy and/or MRI performed. If the subject had a liver biopsy and/or MRI within 6 months of screening, but experienced a weight change of >=5% since the date of liver biopsy and/or MRI, the liver biopsy and/or MRI must be repeated at screening.
• Contraindications to MRI (e.g, claustrophobia, coronary stents, coronary implantable devices, girth, etc.). Stents or other devices may be allowed, at the investigator's discretion, if they do not interfere with the functioning of the MRI machine.
• Current or relevant history of physical or psychiatric illness, any medical disorder that may require treatment or make the subject unlikely to complete the study.
• Treatment with Vitamin E, thiazolidinediones (TZD), or glucagon-like peptide-1 receptor agonists (GLP-1 RA) unless subject on a stable dose for 6 months prior to qualifying liver biopsy and not initiated after qualifying liver biopsy and will continue the same dosing regimen throughout study participation.
• Uncontrolled diabetes defined as HbA1c of >=9.5% within 60 days prior to enrollment.
• Current use of any medication (including over-the-counter, herbal, or homeopathic preparations) that could affect the action, absorption, or disposition of the IP, or clinical or laboratory assessment. (Current use is defined as use within 14 days of screening). Subjects currently taking insulin will not be excluded; however, they must be on a stable dose for at least 30 days prior to screening, or a sliding scale of insulin is allowed as long as the subject's HbA1c remains less than (<) 9.5%.
• Use of drugs, herbs or supplements historically associated with causing or worsening NAFLD/NASH for less than 6 months prior to liver biopsy, or initiated any time after liver biopsy performed, including the use of total parenteral nutrition (TPN).
• Serum aspartate aminotransferase (AST) greater than (>) 7 times upper limit of normal (ULN) at screening.
• Serum alanine aminotransferase (ALT) >7 times ULN at screening.
• Elevated serum creatinine >=2.0 milligram/deciliter (mg/dL).
• International normalized ratio (INR) >1.3
• Total bilirubin (TB) >2.0 times ULN at screening (Except for documented Gilbert's syndrome with bilirubin levels 20 micromole per liter (mcmol/L) to 90 mcmol/L (1.2 to 5.3 mg/dL) and with a ratio of unconjugated/conjugated bilirubin that is commensurately higher).
• Platelet count <130 × 10\^9/liter (L)
• Medical history of impaired hemostasis or use of anticoagulant medication (use of antiplatelet medications, such as low-dose, that is 81 mg, aspirin [ASA] or clopidogrel [Plavix] will be allowed).
• Uncontrolled thyroid disease.
• Type 1 diabetes mellitus.
• Known or suspected intolerance or hypersensitivity to the IP, closely-related compounds, or any of the stated ingredients.
• Known history of alcohol or other substance abuse within the last year or at any time during the study based on investigator's discretion. Weekly alcohol intake greater than 21 grams/day for males and 14 grams/day for females on average or inability to reliably quantify alcohol consumption based on investigator's judgment.
• Within 6 months of MRI and liver biopsy:
• Have used any IP.
• Have been enrolled in a clinical study (including vaccine studies) that, in the investigator's opinion, may impact this Shire-sponsored study.
• Inability to safely obtain a liver biopsy.

Where it is running

• Fresno Clinical Research Center — Fresno, California, United States
• Ceders-Sinai Medical Center — Los Angeles, California, United States
• California Liver Research Institute — Pasadena, California, United States
• Inland Empire Liver Foundation — Rialto, California, United States
• South Denver Gastroenterology, PC — Englewood, Colorado, United States
• Medstar Georgetown University Hospital — Washington D.C., District of Columbia, United States
• George Washington (GW) Medical Faculty Associates — Washington D.C., District of Columbia, United States
• Schiff Center for Liver Diseases — Miami, Florida, United States
• South Florida Center of Gastroenterology — Wellington, Florida, United States
• Internal Medicine Associates of Wellstar Atlanta Medical — Atlanta, Georgia, United States
• Emory University — Atlanta, Georgia, United States
• Gastrointestinal Specialists of Georgia — Marietta, Georgia, United States
• The Queen's Medical Center - Liver Center — Honolulu, Hawaii, United States
• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• Liver Research Center — Louisville, Kentucky, United States
• Tulane University Health Sciences Center — New Orleans, Louisiana, United States
• Louisiana Research Center, LLC — Shreveport, Louisiana, United States
• Mercy Medical Center — Baltimore, Maryland, United States
• Digestive Disease Associates — Catonsville, Maryland, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• University of Massachusetts Medical School — Worcester, Massachusetts, United States
• Henry Ford Health System — Novi, Michigan, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• Kansas City Research Institute — Kansas City, Missouri, United States
• Southern California Research Center — Coronado, California, United States

Full record on ClinicalTrials.gov

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