Automated Measurement of Optic Nerve Sheath Diameter

Completed

Conditions studied: Traumatic Brain Injury, Acute Brain Injuries, Intracranial Hypertension

In brief

Optic Nerve Ultrasound (ONUS) is a promising non-invasive tool for the detection of raised Intracranial Pressure (ICP). Variability in the optimal Optic Nerve Sheath Diameter (ONSD) threshold corresponding to elevated ICP in multiple studies limits the value of ONUS in clinical practice. The investigators goal is to develop and validate an automated image analysis algorithm for standardization of ONSD measurement from ultrasound videos. Patients with acute brain injury requiring invasive ICP monitoring will undergo bedside ONUS, with blinded ONSD measurement by an expert investigator. The image analysis algorithm will then be used to measure ONSD and accuracy determined compared to the "reference standard" expert measurement.

Key facts

Study ID

NCT02786706

Run by

University of Michigan

People needed

75

Starts

2015-07-01

Expected to finish

2019-12-31

Last updated by the study team

2020-12-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admitted to an ICU in the University of Michigan with Acute Brain Injury
• Age> 18 years
• Invasive ICP monitor (external ventricular drain or intraparenchymal catheter) already in place for a clinical indication.

You may not qualify if…

• Pre-existing ocular pathology other than refractive error
• Traumatic globe injury
• Age < 18 years
• Known pregnancy or subsequently discovered pregnancy after admission Prisoners

Where it is running

• University of Michigan Health System — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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