Ketamine in Colorectal Surgery

Withdrawn before enrolling · Phase 4 · Has a placebo group

Conditions studied: Acute Pain, Pain, Postoperative, Colorectal Surgery

In brief

This study will evaluate the effectiveness of ketamine infusions in the management of acute pain following open or laparoscopic colorectal surgery cases. Half of patients will receive the institutional standard of care and a placebo infusion (no active medication). The other half of patients will receive the institutional standard of care and a ketamine infusion. All subjects and staff will be blinded as to whether they are receiving placebo or ketamine.

Key facts

Study ID

NCT02785003

Run by

Medical College of Wisconsin

People needed

0

Starts

2016-07-01

Expected to finish

2018-08-01

Last updated by the study team

2017-10-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than 18 years
• Surgical intervention required for the management of colonic disease
• Admission to either the acute care surgery or colorectal surgery service with an anticipated inpatient hospital stay of 72 hours.

You may not qualify if…

• History of adverse reaction to ketamine
• Chronic opioid therapy for >3 weeks of >30mg oral morphine equivalents per day
• Known substance abuse with prescription opioids or heroin
• Anticipated post-operative intubation (>6hr duration)
• History of psychosis
• Active delirium
• Glaucoma
• Active acute coronary syndrome
• Severe, poorly controlled hypertension (systolic blood pressure > 180)
• Concurrent use of monoamine oxidase inhibitors (MAOIs)
• Pregnancy
• Prisoners

Where it is running

• Froedtert Memorial Lutheran Hospital — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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