A Study to Evaluate the Long-Term Efficacy, Safety, and Tolerability of Repeated Administration of Upadacitinib (ABT-494) in Participants With Crohn's Disease

Completed · Phase 2

Conditions studied: Crohn's Disease (CD)

In brief

This is a open-label extension (OLE) study designed to evaluate the long-term efficacy, safety, and tolerability of Upadacitinib (ABT-494).

Key facts

Study ID

NCT02782663

Run by

AbbVie

People needed

107

Starts

2016-05-18

Expected to finish

2025-07-18

Last updated by the study team

2025-07-31

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant must have completed Study M13-740 through Week 52.
• If female, participant must be postmenopausal, surgically sterile or on using a birth control method.

You may not qualify if…

• For any reason participant is considered by the investigator to be an unsuitable candidate
• Female participant with a positive pregnancy test at Baseline or who is considering becoming pregnant during the study.
• Participant is not in compliance with prior and concomitant medication requirements and procedures throughout Study M13-740.

Where it is running

• Univ California, San Francisco /ID# 149987 — San Francisco, California, United States
• Duplicate_University of Florida - Archer /ID# 150033 — Gainesville, Florida, United States
• The Ctr for Gastro Disorders /ID# 150012 — Hollywood, Florida, United States
• Nature Coast Clinical Research - Inverness /ID# 149975 — Inverness, Florida, United States
• Gastroenterology Associates of Central Georgia, LLC /ID# 149870 — Macon, Georgia, United States
• GI Specialists of GA, PC /ID# 150015 — Marietta, Georgia, United States
• Cotton O'Neil Clinical Research Center, Digestive Health /ID# 149900 — Topeka, Kansas, United States
• Duplicate_University of Louisville /ID# 149884 — Louisville, Kentucky, United States
• Investigative Clinical Research /ID# 149886 — Annapolis, Maryland, United States
• Charm City Research Group /ID# 150040 — Towson, Maryland, United States
• Clin Res Inst of Michigan, LLC /ID# 150008 — Chesterfield, Michigan, United States
• Mayo Clinic - Rochester /ID# 149894 — Rochester, Minnesota, United States
• Kansas City Research Institute /ID# 149888 — Kansas City, Missouri, United States
• Washington University-School of Medicine /ID# 149899 — St Louis, Missouri, United States
• NYU Langone Long Island Clinical Research Associates /ID# 149976 — Lake Success, New York, United States
• Weill Cornell Medicine/NYP /ID# 149895 — New York, New York, United States
• Univ NC Chapel Hill /ID# 149982 — Chapel Hill, North Carolina, United States
• University Of Cincinnati Medical Center /ID# 149977 — Cincinnati, Ohio, United States
• Options Health Research, LLC /ID# 150010 — Tulsa, Oklahoma, United States
• Texas Digestive Disease Consultants - Southlake /ID# 149869 — Southlake, Texas, United States
• Texas Digestive Disease Consultants - Southlake /ID# 149989 — Southlake, Texas, United States
• Aspen Clinical Research /ID# 150020 — Orem, Utah, United States
• University of Virginia /ID# 149881 — Charlottesville, Virginia, United States
• Virginia Mason Hospital & Medical Center /ID# 150042 — Seattle, Washington, United States
• UC San Diego Health System /ID# 150041 — La Jolla, California, United States

Full record on ClinicalTrials.gov

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