Anti-inflammatory Effects of Fiber
Completed · Not applicable
Conditions studied: Postprandial Inflammation
In brief
The main objective of this research is to investigate the effect of addition of fiber on the high fat high carbohydrate (HFHC) meal induced inflammation and oxidative stress mechanisms at the molecular level in humans, in vivo. The investigators have previously shown that the intake of one HFHC meal leads to an increase in oxidative stress and inflammation. HFHC meal also induces an increase in the expression of suppressor of cytokine signaling- 3 (SOCS-3) in the mononuclear cells (MNC), which interferes with insulin signal transduction and contributes to the pathogenesis of insulin resistance. In contrast, an American heart association (AHA) meal rich in fruits and fiber does not induce these effects. These observations are important since HFHC meal not only induces oxidative stress and inflammation but also lays the foundations of a potentially greater insulin resistance through the induction of SOCS-3, TLR-4 and TLR-2.
Key facts
- Study ID
- NCT02781350
- Run by
- University at Buffalo
- People needed
- 20
- Starts
- 2010-11-01
- Expected to finish
- 2013-05-01
- Last updated by the study team
- 2016-05-25
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age: 18 to 80 years of age
- Subject will be available for duration of the study and willing to comply with all study requirements
- Written and informed consent signed and dated
- Nonsmoker
You may not qualify if…
- Coronary artery disease (CAD): documented by history of myocardial infarction, angioplasty/stent placement, angina, exercise EKG positive for ischemia or angiographic evidence of CAD
- Patient on non-steroidal anti-inflammatory drugs or steroids
- Hepatic disease (transaminase > 3 times normal)
- Renal impairment (serum creatinine > 1.5 mg/dl)
- History of drug or alcohol abuse
- Participation in any other concurrent clinical trials
- Use of an investigational agent or therapeutic regimen within 30 days of study
- Pregnancy
- Premenopausal women who are trying to be pregnant
- Anemia
Where it is running
- ECMC Ambulatory Center, 3rd Floor — Buffalo, New York, United States
Full record on ClinicalTrials.gov
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