Steroids in Children Hospitalized With Asthma
Stopped early · Phase 4
Conditions studied: Asthma, Status Asthmaticus, Wheezes
In brief
Asthma is the most common chronic disease of children. A short (3-5 day) course of a short-acting steroid such as Prednisone or Prednisolone has long been the standard of care for asthma exacerbation. Dexamethasone efficacy in asthma exacerbation has been studied in the outpatient setting and was found to be as effective as Prednisone. Dexamethasone has the advantage of shorter course, more compliance, and more tolerable. This has led many emergency departments to provide a 1-2 dose course of Dexamethasone on discharge. Thus, many inpatients have received a first dose of Dexamethasone prior to reaching the inpatient unit, leading to confusion about the best plan for these patients. Many hospitalist pediatricians continue to give a 5-day total course with Prednisone, but some patients have begun to receive a second dose of Dexamethasone 24 hours after the first dose. To our knowledge, no studies have been done to compare the efficacy of these two protocols in pediatric patients requiring hospitalization. The hypothesis is that a second dose of Dexamethasone is as effective as four additional days of Prednisone in hospitalized children with asthma exacerbation. This is an open label, randomized control study comparing these treatments in children age 2-18 hospitalized with asthma exacerbation who have received a first dose of Dexamethasone.
Key facts
- Study ID
- NCT02780479
- Run by
- University of Florida
- People needed
- 6
- Starts
- 2017-03-20
- Expected to finish
- 2017-08-29
- Last updated by the study team
- 2019-06-21
Who can join
Age: 2 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Signed informed consent by legal guardian
- Age 2 to 18 years old
- Admission to the floor with acute asthma exacerbation.
- Received single dose of oral Dexamethasone
- Initial Pediatric Asthma Score (PAS) of 8 or higher.
You may not qualify if…
- Admission to PICU
- Recent steroid use (within 1 month)
- Cardiac disorder, chronic respiratory illness (BPD or CF)
- Stridor
- Bacterial Pneumonia
Where it is running
- Wolfson Children Hospital — Jacksonville, Florida, United States
Full record on ClinicalTrials.gov
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