Prospective Research Rare Kidney Stones (ProRKS)

Recruiting now

Conditions studied: Hyperoxaluria, Cystinuria, Dent Disease, Lowe Syndrome, Adenine Phosphoribosyltransferase Deficiency

In brief

The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of renal dysfunction in these disorders.

Key facts

Study ID

NCT02780297

Run by

Mayo Clinic

People needed

220

Starts

2016-05-01

Expected to finish

2028-07-01

Last updated by the study team

2026-08-07

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of primary hyperoxaluria
• Diagnosis of enteric hyperoxaluria
• Diagnosis of Dent Disease
• Diagnosis of Cystinuria
• Diagnosis of adenine phosphoribosyltransferase deficiency (APRTd)
• Diagnosis of Lowe Syndrome
• Diagnosis of Dent Disease Carrier

You may not qualify if…

• Prior renal failure
• History of liver and/or kidney transplant.

Where it is running

• Mayo Clinic Hyperoxaluria Center — Rochester, Minnesota, United States (enrolling)
• Mayo Clinic Jacksonville — Jacksonville, Florida, United States
• Children's Memorial Hospital — Chicago, Illinois, United States
• Children's Hospital, Harvard Medical School — Boston, Massachusetts, United States
• New York University — New York, New York, United States
• Cincinnati Children's Hosptial Medical Center — Cincinnati, Ohio, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Hosptial of Sick Children — Toronto, Ontario, Canada
• Landspitali Universtiy Hospital — Reykjavik, Iceland
• University of Alabama @ Birmingham — Birmingham, Alabama, United States
• Shaare Zedek Medica Center — Jerusalem, Israel

Full record on ClinicalTrials.gov

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