Microfluidics and Transcriptomics in Post Solid Organ Transplant Patients
Stopped early
Conditions studied: Immunosuppression
In brief
The field of genomics is an exciting new field being applied in medicine. Its use in treating some cancers, sepsis and burn patients has been very promising. As knowledge of genomics and application of microarrays expands, researchers are developing more intelligent ways to provide individualized care for patients. The plan of this research study is to apply the use of genomics as a tool for transplant in several capacities. This research study is designed to develop methods of isolating relevant cell types via microarray plates, then extracting mRNA samples of those cell types and capturing their genetic profile. This will be done with the blood of up to ten healthy donors. Once this ability has been demonstrated, the next step will be to use these testing in several capacities in transplant patients. The research study plan involves following the genetic profile of 26 kidney transplant patients. One group will be followed prospectively starting at baseline, and then at various set time points. A second group will be sampled with the occurrence of clinical events. These events include viral, bacterial, and fungal infection, WBC \< 2.5 or biopsy proven rejection episodes or normal graft function. Thus, the intention of the study is to demonstrate how immunosuppression alters the expression of this genetic expression of these T cells. In doing so, the study will provide a better understanding of the specific and true immunosuppressed state for any given patient.
Key facts
- Study ID
- NCT02776111
- Run by
- University of Florida
- People needed
- 7
- Starts
- 2016-07-01
- Expected to finish
- 2019-06-26
- Last updated by the study team
- 2019-07-01
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy Controls
- consent for blood draw
- Kidney Transplant Group
- actively listed with the University of Florida Kidney Transplant Program (which has its own standards for active listing including not being pregnant),
- consent for blood draw
You may not qualify if…
- Healthy Control
- pregnancy,
- any known organ failure
- Kidney Transplant Group
- none, exclusive to what is listed in inclusion criteria.
Where it is running
- University of Florida — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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