PAV vs Assist Control After Failed SBT
Completed · Not applicable
Conditions studied: Weaning Mode Comparison
In brief
The primary aim of this research is to determine the feasibility of conducting a randomized controlled trial comparing two ventilation modes in patients admitted to the ICU who require mechanical ventilation. The investigators plan to include patients on mechanical ventilation with low support (PaO2/FiO2 ratio \> 200, FiO2 \< 0.5 and PEEP \< 8) for a period no longer than 48 hrs. There are a number of potential barriers to enroll patients in the study. Importantly patients will have to be enrolled within 48 hours from the time they meet inclusion criteria. The secondary aims are to determine the impact of proportional assist-ventilation (PAV) versus volume assist-control (VAC) ventilation by evaluating the number of ventilation-free days, development of Intensive Care Unit (ICU) delirium, use of sedative/ analgesic medications, use of antipsychotic medications, length of stay in the intensive care unit and hospital, reintubations within 24 hours, adverse events, and mortality in the two groups of patients.
Key facts
- Study ID
- NCT02773433
- Run by
- University of Louisville
- People needed
- 20
- Starts
- 2016-01-01
- Expected to finish
- 2016-11-01
- Last updated by the study team
- 2016-12-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age >18 yrs old
- Patient or proxy available in the hospital to consent
- Receipt of invasive mechanical ventilation on low ventilator support (Po2/Fio2 ratio >200, Fio2 <60% \& PEEP <8) for a period not greater than 48 hrs
You may not qualify if…
- Pregnant patients
- Terminal diseases (e.g. advanced or metastatic malignancy, liver cirrhosis with an estimated 3 month mortality > 50%)
- Severely depressed respiratory drive
- Receipt of neuromuscular blocker
- Bronchopleural fistula
- Inability to obtain consent from patients or their proxies.
Where it is running
- UofLouisville — Louisville, Kentucky, United States
Full record on ClinicalTrials.gov
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