Nutraceutical Citrulline in Pregnancy

Stopped early · Not applicable · Has a placebo group

Conditions studied: Type 2 Diabetes

In brief

The purpose of this study is to determine if oral of L-citrulline (3 grams/day) for 3 weeks provided in mid-pregnancy to pregnant women with type 2 diabetes will increase the plasma L-arginine/ADMA ratio, lower maternal blood pressure and increase maternal levels of placental growth factor (PlGF).

Key facts

Study ID

NCT02772887

Run by

University of Pittsburgh

People needed

8

Starts

2016-08-01

Expected to finish

2019-05-01

Last updated by the study team

2019-05-30

Who can join

Age: 14 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Singleton pregnancy
• Type 2 diabetes with hemoglobin A1c <8
• Gestational age at randomization between 14 and 16 weeks based on clinical information
• Maternal age between 14 and 40 years

You may not qualify if…

• Chronic hypertension
• Major fetal anomaly
• Fetal demise
• Planned termination of the pregnancy
• Collagen vascular disease (autoimmune disease) on medication
• Renal disease
• Epilepsy or other seizure disorder
• Active or chronic liver disease
• Heart disease, known illicit drug or alcohol abuse during current pregnancy
• Already taking L-citrulline as a supplement (1gram/day or more)

Where it is running

• Magee-Womens Hospital of UPMC — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.