Pediatric ACL: Understanding Treatment Options

Running, not enrolling

Conditions studied: Anterior Cruciate Ligament Reconstruction

In brief

Pediatric ACL: Understanding Treatment Outcomes (PLUTO) is a multi-center, prospective cohort study. Specific aims of PLUTO are to evaluate the safety and comparative effectiveness of non-operative treatment, as well as four operative treatments including (1) transphyseal ACL reconstruction (2) partial transphyseal ACL reconstruction, (3) physeal-sparing epiphyseal ACL reconstruction using the Anderson technique, and (4) physeal-sparing ACL reconstruction using the Micheli/Kocher technique in prepubescent and pubescent skeletally immature patients.

Key facts

Study ID

NCT02772770

Run by

Boston Children's Hospital

People needed

765

Starts

2016-09-01

Expected to finish

2030-12-01

Last updated by the study team

2025-05-13

Who can join

Age: 5 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosis of complete intrasubstance ACL tear
• Skeletally Immature (by knee radiographs)

You may not qualify if…

• Prior ACL surgery on the ipsilateral knee
• Congenital ACL deficiency
• Multiple ligament reconstruction required
• Other significant comorbidities including syndromic conditions, neuromuscular disorders or developmental delay
• If scheduling of the ACL surgery is impacted by the skeletal maturity of the patient
• Simultaneous bilateral ACL tears

Where it is running

• Stanford University Medical Center — Palo Alto, California, United States
• Rady Children's Hospital — San Diego, California, United States
• Children's Healthcare of Atlanta — Atlanta, Georgia, United States
• Boston Children's Hospital — Boston, Massachusetts, United States
• Washington University at St. Louis — St Louis, Missouri, United States
• Hospital for Special Surgery — New York, New York, United States
• Cincinnati Children's Medical Center — Cincinnati, Ohio, United States
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Tennessee Orthopaedic Alliance — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.