Making Sense of Dyspnea Assessment

Completed

Conditions studied: COPD, Dyspnea

In brief

Dyspnea, or uncomfortable labored breathing, is an important patient-reported outcome (PRO). It is the primary and most disabling symptom of chronic obstructive pulmonary disease (COPD). There is a high priority to improve dyspnea PRO assessment and predict exacerbations. Frequent exacerbations are associated with increased disability, decreased quality of life (QOL), and accelerated lung function decline. Goals: To test the relative sensitivity to change, responsiveness and predictive validity of a comprehensive dyspnea outcome computer adaptive test (CAT) that measures new anxiety and activity avoidance domains and is more efficient to administer than existing dyspnea scales. Expected Outcomes: Investigators expect to: 1. begin to transform how dyspnea is assessed; 2. improve dyspnea symptom management; 3. impact functional status; 4. improve QOL; 5. facilitate the earlier treatment and prevention of exacerbations; 6. improve COPD prognosis and survival; and 7. improve COPD healthcare utilization.

Key facts

Study ID

NCT02771262

Run by

NYU Langone Health

People needed

148

Starts

2014-10-01

Expected to finish

2020-02-01

Last updated by the study team

2020-05-28

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• English Speaking
• Over 40 years of age
• Physician-diagnosed COPD documented in their clinic notes
• Have at least one pulmonary function test (PFT) with a pre-bronchodilator or post-bronchodilator ratio of forced expiratory volume in one second divided by the forced vital capacity (FEV1/ FVC) OF < 0.70 and/or evidence of COPD on chest computed tomography (CT)

You may not qualify if…

• Neurological dysfunction that interferes with their participation in the pulmonary rehabilitation program
• Are unable to provide informed consent
• PR participants who are hospitalized during their PR program will be excluded from further evaluation

Where it is running

• New York University Langone Health — New York, New York, United States

Full record on ClinicalTrials.gov

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