Predictors of Motor Progression in Parkinson's Disease

Completed

Conditions studied: Parkinson's Disease

In brief

Treatment resistant motor features, such as postural instability and freezing of gait are common in people with Parkinson's disease and major contributors to morbidity and mortality. This project will use sleep studies, quantitative motor assessments and magnetic resonance imaging to examine the relationship between abnormally increased muscle activity during rapid eye movement sleep and the development and progression of treatment-resistant postural instability and gait disturbances. Specifically, the investigators will test the hypothesis that anticipatory postural adjustments (weight and pressure shifts) during gait initiation are significantly reduced in people with Parkinson's disease who have abnormally elevated muscle activity during rapid eye movement (REM) sleep compared to individuals will Parkinson's disease whose REM sleep muscle activity is normal. In addition, the investigators will test the hypothesis that the level of RSWA at baseline is predictive of measures of motor decline (postural stability and gait) and alterations in the structure and function of locomotor brainstem networks. Since sleep disorders can emerge years before a diagnosis of Parkinson's disease, establishment of a link between sleep and treatment-resistant posture and gait disorders will help identify individuals at risk of developing these disabling motor features of disease.

Key facts

Study ID

NCT02769039

Run by

University of Minnesota

People needed

72

Starts

2015-10-01

Expected to finish

2019-05-31

Last updated by the study team

2019-06-05

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosis of idiopathic Parkinson's Disease (PD).
• Age 21-75 years
• Able to ambulate independently without the use of an assistive device (e.g. cane)

You may not qualify if…

• History of Dementia
• History of musculoskeletal disorders that adversely affects walking and/or balance
• Other significant neurological disorders
• Implanted deep brain stimulator(s) (DBS) or other neurosurgeries to treat PD
• MRI exclusion for 7 tesla scans: presence of any metallic clips or implantable medical devices
• Pregnant women

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.