Prognostication Biomarkers in Pediatric Cardiac Arrest

Completed

Conditions studied: Cardiac Arrest

In brief

This multicenter study will validate a panel of serum, imaging, and clinical biomarkers to classify patient outcome early after out-of-hospital pediatric cardiac arrest. Results are expected to have a positive and immediate impact in advancing clinical care and outcomes for these children. This work will provide clinicians, families, and researchers with superior tools to assess the severity of brain injury early after resuscitation in order to know who is at risk of brain injury and may benefit from neuroprotective interventions, to monitor response to these interventions, to plan rehabilitation strategy, and to optimize the design of research studies that test novel interventions to improve neurological outcome after cardiac arrest.

Key facts

Study ID

NCT02769026

Run by

University of Pittsburgh

People needed

164

Starts

2017-06-01

Expected to finish

2021-03-01

Last updated by the study team

2021-04-06

Who can join

Age: 0 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children between 2 weeks -17 years of age
• Child had an out of hospital CA: defined as "Cessation of cardiac mechanical activity as confirmed by the absence of signs of circulation. Includes the following rhythms: pulseless electrical activity (PEA), asystole, ventricular tachycardia, and ventricular fibrillation" without a specific duration of CA to capture the full breadth of the range of neurological outcomes
• Children will be admitted to a pediatric or cardiac ICU
• Children have vascular access for blood draws as part of their standard of care
• Children have a pre-CA Pediatric Cerebral Performance Category (PCPC) score of 1-3. 6. The caregivers are required to be fluent in English but some sites may support Spanish-speaking only caregivers

You may not qualify if…

• Patients with acute simultaneous brain lesion (trauma, abscess, tumor, bacterial meningitis)
• Children with do not resuscitate (DNR) status
• Child is pregnant
• Child has an absolute or major contraindication for MRI/S (metal in the eyes, cardiac pacemakers, implanted cardioverter defibrillators, neurostimulation systems, and cochlear implants)
• Child is undergoing brain death evaluation
• Child has metabolic disease affecting the brain

Where it is running

• Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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