A Test of Neural Inertia in Humans With Xenon

Completed · Phase 2

Conditions studied: Neurocognitive Dysfunction

In brief

The dual objectives of this study are to determine if the phenomenon of neural inertia is present in humans and to determine whether the order of neurocognitive function is invariant among anesthetic agents. This study will enroll 24 healthy volunteers, ages 20-40 years, who will receive xenon gas (concentrations ranging from 0% to 60%) delivered via inhaled route through the ENHANCER 3000.

Key facts

Study ID

NCT02768727

Run by

University of Pennsylvania

People needed

21

Starts

2016-04-01

Expected to finish

2021-12-01

Last updated by the study team

2022-07-08

Who can join

Age: 20 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy volunteers ages 20-40 years old
• American Society of Anesthesiologists (ASA) Physical Status I or II (i.e. healthy)
• Body Mass Index <30 kg/m2
• Easily visible uvula

You may not qualify if…

• Any physical signs that would suggest a difficult airway (e.g. mouth opening <3cm, short distance between the chin and neck, poor mandibular subluxation, thick neck)
• History of reactive airway disease
• Current or history of neuropsychiatric disorders
• History or current use of psychotropic medications,
• History or current obstructive sleep apnea
• Current or history of cardiovascular disease or arrhythmias,
• Current or history of chronic sleep disorders
• History of postoperative nausea/vomiting
• Family history of problems with anesthesia (including but not limited to malignant hyperthermia),
• Current or history of Motion sickness
• Current tobacco use
• Current pregnancy or currently breastfeeding
• Positive urine toxicology screen
• History of seizure disorder, head injury, or brain tumor
• Alcohol consumption greater than 12 drinks per week or more than 4 drinks on any single day
• Inability to provide informed consent
• Inability to achieve mask seal on intervention day

Where it is running

• University of Pennsylvania, Perelman School of Medicine — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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