MRI of Glymphatic Clearance During Anesthetic Sedation
Completed · Early Phase 1
Conditions studied: Glymphatic Flow
In brief
This study is to assess the effect of dexmedetomidine anesthesia on glymphatic flow in 5 healthy human subjects as visualized by diffusion tensor MRI. The study is designed to measure clinically established, safe imaging of DTI and cerebral blood flow at baseline, during a continuous intravenous infusion of dexmedetomidine at doses designed to produce anesthesia-induced unconsciousness to simulate natural sleep, and again on return to wakefulness.
Key facts
- Study ID
- NCT02768688
- Run by
- University of Pennsylvania
- People needed
- 17
- Starts
- 2014-07-01
- Expected to finish
- 2017-12-01
- Last updated by the study team
- 2018-01-25
Who can join
Age: 20 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Person aged 20-40 years old,
- American Society of Anesthesiologists Physical Status I or II (i.e., healthy),
- Body mass index ≤ 30 kg/m2,
- Easily visualized uvula,
- Not a current tobacco user
- No history of alcohol abuse/must abstain from alcohol use 24 hours prior to and 24 hours after participation.
- Ability to sign informed consent.
- Able to pass standard MRI safety screening
- Must have a responsible adult available to transport subject home safely after end of experiment.
You may not qualify if…
- Healthy male or females less than 20 years of age or older than 40 years of age
- Any physical signs suggestive of difficult airway (mouth opening 3cm, short distance between the chin and neck, poor mandibular subluxation, thick neck),
- History of obstructive sleep apnea,
- History of asthma
- Neuropsychiatric disorders,
- History of, or current use of psychotropic medications,
- Current tobacco use or history of smoking in past month
- Alcohol use exceeding 2 drinks/day
- History of hypertension or current medication for blood pressure control,
- Cardiovascular disease or arrhythmias,
- Positive urine toxicology screen,
- History of gastroesophageal reflux disease,
- Pregnancy,
- Sleep disorders,
- History of postoperative nausea/vomiting or motion sickness,
- Inability to sign informed consent
- Contraindications for safely participating in MRI imaging study,
- Does not have a responsible adult available to provide transport from HUP MRI area to home.
Where it is running
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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