Investigations of Dementia in Parkinson Disease

Recruiting now

Conditions studied: Parkinsons

In brief

The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.

Key facts

Study ID

NCT02763683

Run by

Washington University School of Medicine

People needed

320

Starts

2016-06-01

Expected to finish

2030-03-01

Last updated by the study team

2026-05-08

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.

You may not qualify if…

• history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia.
• severe systemic diseases.
• inability to lie still for 90 minutes.
• metallic implants, pacemakers, or any other contraindication to MRI.
• refusal to consent to brain donation.

Where it is running

• Washington University in St. Louis — St Louis, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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